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Cancer, Cyclin, and Cdks..

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Cancer, Cyclin, and Cdks..

Postby krengel14 » Fri Dec 02, 2011 3:31 am

I am a junior in high school taking an A.P. Bio course. We are reading about the workings of mitosis, and i read in my textbook that mitosis is regulated by cyclin-dependent kinases, that bind with cyclin to form MPF's. It goes on to say that the cyclin part is degraded during anaphase, if the cyclin is never degraded and the MPF stays intact could this result in a cancer-like repetition of mitosis??? plz help..
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Postby JackBean » Fri Dec 02, 2011 3:40 pm

it is important, that the cyclins are changed during the cycle, that is, for each phase, you need another cyclin. If it wasn't degraded, the cell would be arrested.

Cis or trans? That's what matters.
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