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immunology

Human Anatomy, Physiology, and Medicine. Anything human!

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immunology

Postby BruceWayne » Sun Oct 23, 2011 2:21 pm

Hello everyone This is my first post.

I will have to write an essay on the biological activity of the different immunoglobulin classes and how the structure affects it.
At the moment I am a bit lost. Any guidance on where to start would be much appreciated.

Thank you
BruceWayne
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Postby BruceWayne » Sun Oct 23, 2011 3:07 pm

Hello everyone This is my first post.

I will have to write an essay on the biological activity of the different immunoglobulin classes and how the structure affects it.
At the moment I am a bit lost. Any guidance on where to start would be much appreciated.

I am gathering all the info from my textbook, (but I find it really hard to read) and from this web site which seems quite reliable and I find it very well structured, easy to read and understand. http://pathmicro.med.sc.edu/mayer/IgStruct2000.htm

I have understood (I think) the difference in the structure and the fact that different Ig are located at different sites throughout the body. What I am not to clear on is how to correlate the diffrence in structure with the different activities of Immunoglobulins.
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Postby daniel.kurz » Mon Oct 24, 2011 12:35 am

To help you along you way, think about the ways in which the variable region of the Ig may be changed and that may adjust its binding properties. For the most part, Ig is the same except for the variable region will adjust through recombinant (resultant protein change because DNA--> mRNA --> protein). If you adjust the variable section, amino acids will change in the variable region and if we conclude that certain amino acids have specific binding properties then the whole region may have different resultant binding properties.

That is a good website that you have picked. I hope that I helped you along.
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Postby BruceWayne » Thu Oct 27, 2011 2:16 pm

Thank you. It did help.
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Re: immunology

Postby Xaolou » Mon Mar 19, 2012 4:01 pm

It is an interesting topic. How far have you come? Likewise, i've to work on antibodies for a while. I'm in the middle of the research process now. I also try to look at and try out some manufacturers such as GenScript, which offers a range of products from bio-reagents to bio-essays. Well it might be nice to share some outcomes of the studies here..Good luck you all!!:)
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