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Strength of anesthetic drugs

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Strength of anesthetic drugs

Postby Anna55 » Wed Sep 21, 2011 4:36 pm

1) The strength of anesthetic drugs are roughly proportional to their ability to dissolve into lipid (fat). This is also true for different alcohols. 2) In the 1950s it was pointed out a correlation that the larger the volume of the anesthetic molecule the stronger the effect. The cell membrane can be thought of as a fluid structure in which proteins can move about dependent upon the fluidity of the lipids. Why is point 1 and 2 true about anesthetics?

This is my theory; if an anesthetic drug is easily dissolved into lipid, it will also dissolve easily into the cell, since the plasma membrane consist of a phospholipid bilayer. If the volume of the molecule is greater, it will trigger more chemical reactions in the cell, thus creating a stronger effect of the anesthetic drug.

Is my theory correct? If not, where is my error? How can I develop my theory? Thank you in advance!
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Postby JackBean » Thu Sep 22, 2011 9:17 am

I would rather say, that it will pass into the cell (not dissolve into cell), but otherwise OK.
However, I'm not sure about the size of molecule. Are you sure, it's size of molecule and not dose? (although that would be quite obvious :) )
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: Strength of anesthetic drugs

Postby Anna55 » Fri Sep 23, 2011 4:01 pm

Ok, thank you for the advice! Yes, it is the size of the molecule. Yes, indeed!
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