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Questions regarding GPCR terminology

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Questions regarding GPCR terminology

Postby alwang17 » Sun Jul 24, 2011 9:17 pm

Hi all! I'm doing a presentation on an article regarding the dopamine D1 and D2 receptors in oligomers and how they change. The article in question is:

Separation and reformation of cell surface dopamine receptor oligomers visualized in cells
From the European Journal of Pharmacology.

Essentially, my dilemma is that I don't understand a bunch of technical terms in the article (I'm going to be a high school senior but I'm taking a summer course about GPCRs). Anyway, I'd greatly appreciate it if you guys could help me out with this. Even better, if someone is willing to read the article and help me out with specific sections. I can email the pdf of the article if needed. I can always search up compound names and processes, but some general terms are confusing and ambiguous. And if what I post isn't enough, I'll be glad to provide more info regarding context and whatnot. I'll probably be adding more terms as I progress through the article. Thanks in advance!

Co-internalization and trafficking


Dynamic regulation

Conformationally sensitive
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Postby JackBean » Sat Jul 30, 2011 6:19 pm

well, I'm not expert in this, but in the context of dopamine receptors the explanations should be as follows:

co-trafficing is probably translocation of a protein at higher distances (like from ER to cell membrane), while co-translocation I would understand as translocation of a protein across (single) membrane

dynamic regulation means, that the conditions change and thus the regulation change (e.g. at one moment more receptors are needed, thus the receptors are translocated to the cell membrane, while a while latter they are not needed and are translocated back.

conformationally sensitive probably means, that the proteins (the receptors, right?) respond only with particular conformation, but not with other. For example, the voltage-gated channels in neurons are enclosed by one domain and then they do not respond to new stimulation.

Cis or trans? That's what matters.
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