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Do tumors have functioning mitochondria?

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Do tumors have functioning mitochondria?

Postby treehouse » Tue Jul 19, 2011 11:01 pm

While I have not yet found a satisfactory description of his research methods, I am aware that at the Nobel Prize winning biologist Otto Heinrich Warburg believed at least from 1924 to 1966 that cancer cells generate their ATP primarily from anaerobic metabolism. He was awarded the Nobel Prize in Physiology in 1931.*

If supplied with the same amounts of the same reagents healthy cells use to make ATP, can tumors make as much ATP as healthy cells? What I am wondering is whether tumors' low rate of aerobic metabolism is due to a poverty of supply or an intrinsic inability.

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Postby JackBean » Wed Jul 20, 2011 6:15 am

I would say they have mitochondria (why should they get rid of them?), but the anaerobic metabolism is faster and also you're not dependent on oxygen supplies, which may be insufficient for a big tumor.

But I'm no expert in cancer.

Cis or trans? That's what matters.
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Postby nebeyuasrat » Fri Jul 22, 2011 1:28 am

from my understanding i beleive that tumors are facultative anaerobes but for some reason that i can not explain they prefer the anaerobic way of producing ATP but this does not mean they don't have a mithochondria i just beleive it is easier for them to produce ATP anaerobically
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