organophosphate esters

[sotongette]

Hi all

Organophosphate esters are neurotoxic and have been used in chemical warfare as well as our household pesticides. They basically act to inhibit acetylcholinesterase to prevent the breakdown of ACh in our synapses.

Question here is, why are they do different in toxicity? Some OP are so low in potency tt when used in pesticides are not that harmful to humans, but some OPs are so potent that it could be easily taken in via the skin and causes acute neurotoxicity.

Any kind souls out there who can help to explain? Thanks in advance!