Login

Join for Free!
113947 members


How do receptor proteins get into urine??

Discussion of all aspects of cellular structure, physiology and communication.

Moderator: BioTeam

How do receptor proteins get into urine??

Postby bs07cp » Fri Apr 15, 2011 10:19 pm

Hello

Im a bit embrassed to ask my professor/supervisor this question becuase it is probably very simple...

I am doing a research project based on identivying a binding antibody to the cell surface transmembrane protein known as 'FGFR3' which is being developed as a biomarker urine test for bladder cancer (urothelial cell carcinoma), due to overexpression and/ or mutational activation.

A question ive been asked my a professional is 'how would this protein get into the urine'??

Ive been thinkin about this question..and i am thinkin that it could get excised by membrane-associated proteases releasing the soluble extracelular domain into the extracelular space of epithelial bladder tissue....but wondering ow it would find its way in to the urine of the patient?? Any ideas...maybe glomerula filtration in the kidneys...

Thanks, callum
bs07cp
Garter
Garter
 
Posts: 1
Joined: Fri Apr 15, 2011 9:41 pm

Postby canalon » Sat Apr 16, 2011 2:08 am

Dead epithelial cells peeling off the bladder membrane and being evacuated in the urine?My 2 cents.
Patrick

Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
User avatar
canalon
Inland Taipan
Inland Taipan
 
Posts: 3909
Joined: Thu Feb 03, 2005 2:46 pm
Location: Canada


Return to Cell Biology

Who is online

Users browsing this forum: No registered users and 1 guest

cron