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Question about CJD

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Question about CJD

Postby Brodo » Thu Mar 31, 2011 5:24 am

I would just like to confirm my understanding of CJD (creutzfeldt Jakob Disease)

My notes say that the PrPc protein is converted by some unknown protein x into PrP*
Would this protein x be the prion?

Also, the effect of this conversion is that the PrP* will use a PrPsc protein as a template to convert PrP* into another PrPsc. Where did this initial PrPsc protein come from?

Thank you
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Postby Darby » Thu Mar 31, 2011 3:21 pm

The assumption is that the protein is maybe from a mutated code, with a change that a) makes it fold up differently, and b) produces a form that can reconform the "regular" version into something like it.
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Re: Question about CJD

Postby Brodo » Thu Mar 31, 2011 11:10 pm

Okay, thanks.
But is protein x a prion?
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Postby canalon » Fri Apr 01, 2011 3:06 am

generally yes.
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