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Terminal Differentiation

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Terminal Differentiation

Postby moomoosacow » Tue Mar 08, 2011 7:44 pm

Is it true that in all cases terminally differentiated cells do not divide?
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Postby Julie5 » Fri Mar 11, 2011 3:07 pm

Hi - I have a feeling (OK, actually dim and uncertain memory!) that they used to think they didn't, now they think they might....

Anyone know more precisely please??
(I got this out of reading up on cancer, where there seems to be conflicting information about whether only the stem cells in a tissue can be malignantly transformed, or whether terminally differentiated tissue cells can also be malignantly transformed, in which case the latter must still be dividing....)
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Postby JackBean » Mon Mar 28, 2011 11:32 am

I think that mostly they are still slowly dividing, just sometimes (like for neurones), they're stucked in G0 for years

Cis or trans? That's what matters.
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