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Protein Localization

Everything on bioinformatics, the science of information technology as applied to biological research.

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Protein Localization

Postby rosegarden » Tue Feb 22, 2011 1:54 am

Hey guys, so I'm given a long strand of protein (shown below). It is predicted to be nuclear localized but how can I know that it's nuclear localized just by looking at its primary sequence? I mean we can probably do some protein tagging to localize it experimentally but I have no idea how the prediction part comes about. Thanks in advance for any help.

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Postby canalon » Tue Feb 22, 2011 3:13 am

Patrick

Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
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Postby rosegarden » Tue Feb 22, 2011 3:52 am

I have used predictor tools but I want to know how to predict localization just by looking at the primary sequence.
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Postby JackBean » Tue Feb 22, 2011 6:35 pm

but that's what the predictors do, they look on the primary structure and look for specific patterns, which could mean localisation into any organelle
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: Protein Localization

Postby rosegarden » Wed Feb 23, 2011 12:14 am

does this have something to do with locating a part of the main sequence called the nuclear localization signal with indicates nuclear localization? and if so what is the sequence of the nuclear localization signal?
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Postby JackBean » Wed Feb 23, 2011 9:13 am

http://www.biolib.cz/en/main/

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