Login

Join for Free!
119197 members


Porphyrias and hemoglobin

Human Anatomy, Physiology, and Medicine. Anything human!

Moderator: BioTeam

Porphyrias and hemoglobin

Postby jakov03 » Tue Oct 26, 2010 9:59 pm

Hello!
I have heard something about porphyrias and after that I have studied the pathogenesis and biochemistry of this illness. I know that it is a metabolic disorder in heme synthesis. But what I really want to know is how this people have hemoglobins at all, if they can not synthesize the heme?
Feel free you can explain by the bichemical method; on the contrary I am alraedy searching for something such like this.

Btw, I am student and sorry for my bad english. :D
Thank you! :wink:
jakov03
Garter
Garter
 
Posts: 5
Joined: Tue Nov 03, 2009 12:41 am

Postby Babybel56 » Sat Apr 23, 2011 7:57 pm

The enzymes are not totally inactivated and cause a drop in haemoglobin production, not a complete cut-off. This isn't the main problem with the disease either: they can still function with this amount. Rather it's the accumulation of the precursors (called porphyrins), which are toxic to the body and cause the symptoms of acute porphyria.
Babybel56
Death Adder
Death Adder
 
Posts: 65
Joined: Mon Apr 18, 2011 11:35 am
Location: University of Cambridge, UK


Return to Human Biology

Who is online

Users browsing this forum: No registered users and 1 guest