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Tissue Infection?

About microscopic forms of life, including Bacteria, Archea, protozoans, algae and fungi. Topics relating to viruses, viroids and prions also belong here.

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Tissue Infection?

Postby sam2400 » Sun Oct 10, 2010 10:42 am

Hi

Basically I would like to know how bacteria move through a tissue that they are infecting. The example I am studying is a Urinary tract infection, ( acute pyelonephritis ). Once the Bacteria, E. coli in this case, have colonised the UT and moved up into the kidneys, how do they infiltrate the tissues of the kidney. I am assuming they utilise enzymes and pili/receptors to break throught the extracellular matrix and infiltrate the kidney tissue? However I have not found any evidence for this yet and have had trouble finding any.

If anyone could provide any answers for this I would be much obliged, papers/references if possible.

Thanks
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Postby alchilito » Sat Oct 23, 2010 12:42 am

Much of the tissular damage stems from inflammatory reactions triggered by microbial products like LPS, peptidoglycan, n-formyl proteins, etc. Virulence factors you mention also play a major role.
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