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Human Anatomy, Physiology, and Medicine. Anything human!

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Postby London » Sat Dec 02, 2006 11:01 pm

A Human Opsin-Related Gene That Encodes a Retinaldehyde-Binding ProteintJ

ABSTRACT: The ligand-binding property of a cytoplasmic membrane-bound protein from bovine retinal
pigment epithelium (RPE) has been demonstrated. The putative RPE-retinal G protein coupled receptor
(RGR) covalently binds both all-trans- and 1 1 -&retinal after reduction by sodium borohydride. The
32-kDa receptor binds all-trans-retinal preferentially, rather than the 1 1 -cis isomer. The amino acid
sequence of the opsin-related protein in humans is 86% identical to that of bovine RGR, and a lysine residue,
analogous to the retinaldehyde attachment site of rhodopsin, is conserved in the seventh transmembrane
domain of RGR in both species. The human gene that encodes the novel retinaldehyde receptor spans 14.8
kb and is split into seven exons. The structure of the gene is distinct from that of the visual pigment genes.
These findings support the notion that the rgr gene represents the earliest independent branch of the
vertebrate opsin gene family. A second form of human RGR in retina is predicted by alternative splicing
of its precursor mRNA. This RGR variant results from the alternative use of an internal acceptor splice
site in the second intron of the human gene, and it contains an insertion of four amino acids in the connecting
loop between the second and third transmembrane domains. Since RGR binds all-tramretinal preferentially,
one of its functions may be to catalyze isomerization of the chromophore by a retinochrome-like mechanism.

For more of the document, see:

http://pubs.acs.org/cgi-bin/abstract.cg ... sid=6006l3
London
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Postby London » Sat Dec 02, 2006 11:03 pm

A Human Opsin-Related Gene That Encodes a Retinaldehyde-Binding ProteintJ

ABSTRACT: The ligand-binding property of a cytoplasmic membrane-bound protein from bovine retinal
pigment epithelium (RPE) has been demonstrated. The putative RPE-retinal G protein coupled receptor
(RGR) covalently binds both all-trans- and 1 1 -&retinal after reduction by sodium borohydride. The
32-kDa receptor binds all-trans-retinal preferentially, rather than the 1 1 -cis isomer. The amino acid
sequence of the opsin-related protein in humans is 86% identical to that of bovine RGR, and a lysine residue,
analogous to the retinaldehyde attachment site of rhodopsin, is conserved in the seventh transmembrane
domain of RGR in both species. The human gene that encodes the novel retinaldehyde receptor spans 14.8
kb and is split into seven exons. The structure of the gene is distinct from that of the visual pigment genes.
These findings support the notion that the rgr gene represents the earliest independent branch of the
vertebrate opsin gene family. A second form of human RGR in retina is predicted by alternative splicing
of its precursor mRNA. This RGR variant results from the alternative use of an internal acceptor splice
site in the second intron of the human gene, and it contains an insertion of four amino acids in the connecting
loop between the second and third transmembrane domains. Since RGR binds all-tramretinal preferentially,
one of its functions may be to catalyze isomerization of the chromophore by a retinochrome-like mechanism.

get this...................

MATERIALS AND METHODS
Materials. Human genomic DNA clones were isolated from
a XFIXII bacteriophage library (Stratagene, Inc., La Jolla,
CA), which was constructed from human placental DNA by
the insertion of partially digested Sau3AI DNA fragments
into theXhoI cloning site.

why that's nice, eh? Looks like I might have to turn republican afterall!

For more of the document, see:

http://pubs.acs.org/cgi-bin/abstract.cg ... sid=6006l3
London
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Postby London » Sat Dec 02, 2006 11:14 pm

Now it looks like we are making some progress.....have not checked these out yet......

but I googled: Chitosan-Enzyme Films for Amperometric ( it was just something I had read but had no idea what it meant so I googled it and look what I got:)

http://www.google.com/search?q=Chitosan ... f8&oe=utf8

WEll would 'nt you know....its the good ole biofuel cells......

lame as gov't!

okay, so I was playing around with the 4th one down on the google page and I found it to be "Gene cards" but....the thing that I got from it...was right at the very bottom of the page it said in small letters:

Developed at the Crown Human Genome Center & Weizmann Institute of Science

hmmmm......good ole jewish Weizmann again.....all the way over there....I had them in my file already and was amazed at the PLASMA work they do....talking about something something....go visit that University. Wonder how much of my tax dollars went to them? HUH?
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Postby RANDY » Sat Dec 02, 2006 11:25 pm

I'm back after resting from three days of attack on this board and at home. All is in the hands of attorneys now so attack away if you so wish. I want to thank the lovely people of this board for defending me.

I originally came, not only to defend myself but to post some new info. I found on nanotechnology after getting some ideas from Jan's samples after the rense show and their use by certain companies of which I have no problem naming, they advertise as communication devices as well as other uses and are open to the free market. I've got to get cleaned up after resting from my assault. I do believe this person has been duly warned that she is now being monitored by a number of individuals, companies and their legal firms and hopefully will stay within reasonable bounds on this site and others. She has been blocked from my personal email as that was as full of the caca as was this site


OH MY G_D!!!Sarah Burnheart what a show! Bravo! Bravo! Take a bow!

Total bullshit and lies once again. You are pathological.

No lawyer would take a case where you are threatening me. The police have been called and I had to file a report using your e-mails to me and I am the second person that has had to do this with you Karen.

Stop the BS-ing and the stuff I said about you..you would have to take a drug test to prove me guilty of saying anything untrue and that ain't gonna happen.

So monitor away ( in your mind) and feel sorry for yourself.

Like I or whoever is typing this said...over 10 people have access to my office and my computer....and that is a fact....so stop bullshitting.

You have no case and no one is monitoring this site....all lies and stuff you make up in your head. Really rather sick.

Remember you have been already reported to the police once for threatening someone of something they did not do and leaving threats on their voice amil..better be careful before they come and take you away in white outfits.

You are out of control and dangerous. Like I said, my county police knows your name, address and have copies of your threats to me that you did via private e-mail. I had to block you e-mails. You did nto blcok mine so another huge lie. And you continued to e-mail me and I bounced them back to you. (They go in my delete file) You truly are a patological bs-er.

Cut the s**t out already and leave me alone. I already blocked your e-mails and the only way you can get through to me is via this site.

No one wants to hear this Karen..especially not me.
Leave me alone already! OK!

Randy

Had to defend myself people..will not let her BS get further than one step. I did not start this, this time. Give me that one.
Last edited by RANDY on Sat Dec 02, 2006 11:27 pm, edited 1 time in total.
During the End Times, Good will battle Evil. Where do you stand?
http://unknownskindisease.com
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Postby London » Sat Dec 02, 2006 11:26 pm

so now I'm playing along with google and looking at Gene Cards when out from the blue, I spotted....now get this.....our us president just went there on Wednesday of last week......

where London???? TO ESTONIA!!!!!!!

I FOUND THAT THEY HAD AN ESTONIAN GENOME PROJECT.......

HERE YOU GO:

http://www.geenivaramu.ee/index.php?ots ... g&lang=eng

and

http://www.geenivaramu.ee/index.php?lan ... ised&id=59
__________________________________________________

Randy, FYI....I had no idea she meant you. Hell, I did not even read all of you guys post last week due to being gone out of town. I really don;t think she was insinuating you, but, hell, what do I know.
__________________________________________________

What is this? News to me.....

_http://www.p3gconsortium.org/about.cfm_________

what was the purpose of the NSF fibr projects?

was it b/c of this in the waters?

http://www.pubmedcentral.nih.gov/articl ... &tools=bot
London
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Postby Ridgewalker » Sat Dec 02, 2006 11:54 pm

This should clear up ANY further questions regarding financial information of the MORE JAMM and any borrowing or use of funds by me or any other person or entity. Quesions may be directed to Dr. Wymore at the address shown below.

To Whom it may Concern,

It has been brought to my attention that there are some rumors that Karen Marsh has been borrowing money or taking money away from the Morgellons Research at OSU. There is no mechanism whereby such an action is even possible, either from the Wymore lab research funds or the OSU Foundation funds, let alone probable. Furthermore, Karen has made multiple donations of research money, both personal and from proceeds from the More JAMM. To date, there have been no disbursals or use of any of the Morgellons Funds that have been donated to the OSU Foundation's Morgellons Research, Education and Treatment Fund.

If there are any specific questions regarding donations or this matter, please contact Randy S. Wymore at: Morgellons@okstate.edu.

Sincerely,

Randy S. Wymore, Ph.D.
Assistant Professor of Pharmacology & Physiology
Oklahoma State University
Center for Health Sciences and
College of Osteopathic Medicine
1111 W. 17th St.
Tulsa, OK 74107

email: Morgellons@okstate.edu
office: (918) 561-1135
lab: (918) 561-8290
FAX: (918) 561-8276

Notice: This e-mail message, together with any attachments, contains information that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify me immediately by reply e-mail and then delete it from your system.
Ridgewalker
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Postby msc » Sun Dec 03, 2006 12:46 am

from msc

Thank you for the two websites n renova and tretinoin retinal a.
the website on renova states there has never been any complaints filed.
well have out right lying and deceiving any potential person who might want to try that cream. the following file number was assinged to my
friend by R.W. Johnson Research Beth Price, PRIUSA200000985 back
in 2000. My friend never heard from her nor Johnson Johnson nor McNeill Ortho. after that. My friend sent many letters, her sister tried calling them
e mailing them and even sending them samples of her hair and clothing
and what the bleached retinoids were doing to her clothing and hair
follicles and the dark organisms that was visibly seen in the containers.
she, also, used that file number and sent to the cdc, fda, medwatch,
nj medical examiner, nj consumer protection agency, fbi their no. 0209,
cong. lobiondo who sent her federal laws on how it is federal law for
a drug to be mislabeled and adultered. the prescription shows certain
ingredients and the patents 4877805 4603146 4423041 show about fifty
other chemicals and drugs used such as accutane, isotretinoin, etrinate,
tegison, numerous toxic tetinoids used not just one, chemo therapy agents and radio active agents, isotopes, etc. the one adverse effect you gave us was on tretinoin retinal a, which is one of the ingredients in this.
we can't get any lawyer who are handle the various lawsuits on accutane
and tretinoin and isotretinoin to help us, we don't know why, and it is a
violations of rights having a person being infected with a bacteria infection and infecting her children and co workers, etc. etc. is also a
violation of NJSA 34:19-3. we see websites full of labs that do all of this
toxicology tests for these chemicals, we know cholestrol test would show
mutated synthetic lipids, no one does a test for that, we know that a pulmonary function test proved silica, but allergist refused to do the two other tests required for medical evidence, he did not want to be a witness
in a lawsuite, viollaton of a patients right to diagnosed and treated and
like abestos it falls onto family members cloting in wash etch. , we know
retinoids are stereoisomers and would show up in blood serum, we
know retinoids are from bacteriorrhodopsin, and we know she wrote physicians about the purple glob that she could feel dripping from her temple and forehead and how heavy it was and that we it illuminates she
could see a purple glob, and we just found out last week that bacteriorhodopsin is a purple glob membrane and that it illuminates, and it is used as a computer memory chip and it can hold 25.4 kbits per
univ of arizona 1993 masud mansuripur-- DNA, Human Memory, and the Storage Technology of the 21st century

http://www.optics.arizona.edu/masud/odspaper.pdf

we know from a nurse that prednilone makes bacteria grow, bateriorhodopsin causes biofilms, lecithin induces fungus, we know rhodopsin creates crystal structures, we know they produce ligands
we ligands create claws, and used as chelators, we know they create
atomic clouds, we know polmerizaton was used and products from kobo flourescent pigments and advanced polymers sys inc. bio chips and plastics. we know all of this and now we need someone to prove it.
we need the media to help us and they keep our documents and don't respond even knowing there are inncocent children involved, my friends
photos are more horrifying then you can imagine. we know sol gel was
used and edgma the silicate acrylate causes chromosonal damage per
pdr book (physicians desk reference proving all physicians knew adverse
side effects and what tests needed to be done and by law must file
a fda form 3500a, that was not done either, my friend filed one and
fda says it needs two people to file a complaint to investigate. how
many people filed and the fda told them the same story. look how many
file on accutane, tretinoin which was used in this product. please keep
print outs of our posts, they are preventing me from posting and are
playing with prompts of loggining in.
msc
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Postby London » Sun Dec 03, 2006 1:19 am

good MSC, glad you could use them. On one of my post today i listed what I googled to get them......find that post and google it. i think it was vinyle esters and fibre optics.

Ridgewalker,

for your ear.....it's no damb infection! Don't let them talk you into believing that crap! THEY FRIGGIN LIE, LIE, LIE.

HERE, READ THIS....Your hearing is from the sound waves that are going to make us all go deaf. it's not some damn infection. its permanent.

they are prob pushing the coclear implant,. let me guess......i bet you anything you got hearing info from greema./aka jan smith......

to that....hahaha just as I imagined. (not being rude towards you Ridgewalker, not At all!)

just don't believe you have an ear infection.....,maybe severe damage....but of course they would not tell you that.....

here you go.....you poor thing, put thru hell and back X5

http://www.ilo.org/encyclopedia/?doc&nd ... =0&ssect=1


well, here, be my guest at the whole google page......

love to you~

http://tinyurl.com/y9buy4


talking some cerebral spreading of some hypofusion here or what??? spreading some cortical depression rounds to all of us....no S! I swear that is what the phucksticks are doing.

migrane headaches anyone? check.
Last edited by London on Sun Dec 03, 2006 2:08 am, edited 1 time in total.
London
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Postby J Jill » Sun Dec 03, 2006 1:55 am

London,

You are blowing out the margins with the lengthy link addresses-

Please just edit them and move a portion of the link down one space

It will still be usable- maybe cut and paste-

That, or use Tiny url

http://www.tinyurl.com

Thanks,

Jjill
"When you dine with the devil, bring a long spoon."
Machiavelli
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Postby London » Sun Dec 03, 2006 2:12 am

sorry and thanks Jjill., I fixed that one. I thought the tiny url was a lymebusters thing and I had no access.

Hey Jjill or anyone else that might know.....I thought our gov't did not use dioxin annymore. Whats up with this?

Like I said, I think we have some type of wheat fungus in us so that is how I found this next article.

The potential for aerobic mineralization of [U-14C]dibenzo-p-dioxin (DD) was investigated in samples of three different agricultural soils already contaminated with polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) by industrial activities. The influence of amendments, i.e. wheat straw and compost, and of soil treatment by inoculation with lignolytic fungi, grown on wheat straw substrate, was tested. All the soils tested contained an indigenous DD-mineralizing microflora. The soil characterized by the highest organic matter content and the highest content of soil microbial biomass displayed the best DD mineralization of 36.6% within 70 days, compared with the two organic-matter-poor soils with an endogenous DD mineralization of 19.5% and 23.3% respectively. Amendments with compost increased DD mineralization up to 28% in both soils with low organic matter and microbial biomass content, but did not affect mineralization in the organic-matter-rich soil. Addition of wheat straw had no constant influence on DD mineralization in the soils tested. The best DD mineralization resulted from inoculation with lignolytic white-rot fungi (Phanerochaete chrysosporium, Pleurotus sp. Florida, Dichomitus squalens) and with an unidentified lignolytic fungus, which was isolated originally from a long-term PCDD/F-contaminated soil. A mineralization of up to 50% within 70 days was reached by this treatment. The influence of inoculated fungi on mineralization differed between the soils investigated.

http://www.springerlink.com/content/rqxp3t3ncnxufnrv
London
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Postby London » Sun Dec 03, 2006 2:16 am

London
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Postby Ridgewalker » Sun Dec 03, 2006 2:50 am

London,

I haven't gotten information from anyone on this ear problem. Haven't even talked to my doctor about it. Too hard to explain. So I'm looking to YOU, my friend to help me understand what is happening. You and the other brilliant folks here. I was wondering if anyone had experienced this symptom and what information they had found about it. I don't communicate with greema and the times I have, I haven't received a reply, so no, I came directly here for help. So Heeeelllpp! London!
I haven't had time to read your info. perhaps it explains more. I've had my time wasted by 'other issues' and will not be distracted further.I appreciate all your help!
Ridgewalker
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