Human Anatomy, Physiology, and Medicine. Anything human!
".3 Phage Therapy
An interesting emerging alternative to antibiotic therapy -- and a small step towards nanomedicine -- is phage therapy [14-27]. consume andBacteriophage viruses are tiny biological nanomachines that were first employed against bacteria by d'Herelle in 1922  but were abandoned therapeutically (and then superceded by antibiotics) after disappointments in early trials . Bacteriophages may be viewed as self-replicating pharmaceutical agents  that can destroy pathogenic bacteria when injected into infected hosts. A single E. coli cell injected with a single T4 phage at 37°C in rich media lyses after 25-30 minutes, releasing 100-200 phage particles; if additional T4 particles are added >4 minutes after the first, lysis inhibition is the result and the bacterium will produce virions for up to 6 hours before it finally lyses . Of course, medical nanorobots will not be self-replicating .
With the relatively recent realization that phages have a very narrow host range , success rates of 80-95% have been reported  and interest in phage therapy as an alternative to antibiotics is reawakening . For example, 106 E. coli bacteria injected intramuscularly into mice killed all of the animals (100% mortality), but the simultaneous injection of 104 phage virions specifically selected against the K1 capsule antigen of that bacterial strain of E. coli completely prevented death (0% mortality) . Soothill  found that a dose of 1.2 ×107 virions of a bacteriophage targeted against a virulent strain of Pseudomonas aeruginosa protected half of the mice who were challenged with 5 LD50 of the bacterium; as few as 100 virions of another phage specifically targeted against a virulent strain of Acinetobacter baumanii protected mice challenged with 5 LD50 (108 CFU)* of the pathogen. Interestingly, an oncolytic virus has recently been reported .
One practical difficulty with phage therapy is that even in the absence of an immune response, intravenous therapeutic phage particles are rapidly eliminated from circulation by the reticuloendothelial system (RES), largely by sequestration in the spleen . But Merril et al  found that splenic capture could be greatly eliminated by the serial passage of phage through the circulations of mice to isolate mutants that resist sequestration. This selection process results in the modification of the nature of the phage surface proteins, via a double-charge change from acidic to basic which is achieved by replacing glutamic acid (- charge) with lysine (+ charge) at the solvent-exposed surface of the phage virion . The mutant virions display 13,000-fold to 16,000-fold greater capacity to evade RES entrapment 24 hours post-injection as compared to the original phage . But one concern is that since evasion of entrapment allows increased virulence for most pathogens, widespread use of such modified virus could make possible species jumping of the altered phage genes, especially if the virion is RNA-based and has a high mutation rate. Nanorobotic agents entirely avoid this risk.
* The number of bacterial cells present is often reported as colony-forming units, or CFU.
and the nano would avoid all this. Wonder if it was bacteriophages that caused the mutations of what we call Mendelien diseases. HUH!
Oh and jumping specied, Gerberding, makes the Bird Flu jump right in there doesn't it?
What a mess we have!!
in the above I was talking psychopharmaceutial drugs that would be given by the dermatologist pretending to be a psychologist.
Wow, NANO MEDICINE>>>>>>>>
http://www.foresight.org/Nanomedicine/G ... 0small.jpg
This is the most dumb statement these EVO DEVO's have come up with:
Parasitemia arises from parasites that have evolved to live in the bloodstream
And WHERE IN THE HE.. DO THEY EVOLVE FROM ........that Da.. Biofilm that forms and that flagella that rips into the bacteria and that nanorobot that will go remove the microbes? BS
That new evolving TREE OF LIFE will be swept away by the Black Wind, friends of the devil stir up.
When one has head up arse, and cannot see the loss they are going to have when nature starts to complain, well, I do not think I will cry for them. But, I cry for the loss of those who have had no idea.
A whole crapload of stuff. NEED A SHOVEL>>>>>>>
http://starcentral.mbl.edu/microscope/p ... geid=23394
Oh this would explain how the parasites evolve:
The deadly trypanasome parasite, which infects thousands of Africans with sleeping sickness each year, evades the human immune system by repeatedly changing its molecular coat. A new study describes how this happens. The key is an unusual transcription factory in the cell that switches genes on and off to produce the diverse coats that cover the parasite.
Miguel Navarro and Keith Gull, of the University of Manchester's School of Biological Sciences in Manchester, U.K., found that those factories produce one of a family of variant surface glycoprotein (VSG) genes at any given time. By making such rapid coat changes, the Trypanosoma brucei parasite confuses the human immune system, which is unable to mount an effective response to kill the parasite.
The researchers used green fluorescent protein tags to show that the VSG expression sites are produced outside of the ribosome-producing nucleolus. They call the newly-defined structure the Expression Site Body (ESB).
"The ESB that we have identified represents direct evidence for the existence of a highly defined individual transcription factory," the researchers write in Nature. Their model, which links such ESB factories to particular genes, could help to explain similar expression characteristics in malaria and other parasites.
. . .
http://www.genomenewsnetwork.org/articl ... coat.shtml
this could be catalyst to alter our genes.
this could be catalyst to alter our genes.
Or could this be a way to eliminate a segment of society? What does everyone with Morgellons have in common? Compromised immune systems? Or is it something to do with our genes?
oohh Sky troll what has gone the way of dino...
let me hear a euclidian and reimannian phase out....
this could strike at the core of the academics.. .. . im out on a limb here and im prepared to be flamed and condemed a straight geek.
just a word from Dr. Ruggero Maria Santilli
HYPERSTRUCTURAL BRANCH OF HADRONIC
MECHANICS AND ITS ISODUAL
5.1 IN PREPARATION - NOVEMBER 1, 2005
In this author’s opinion, the biggest scientific imbalance of the 20-th century has been the treatment of biological systems (herein denoting DNA, cells, organisms, etc.) via the mathematics, physics and chemistry developed for inanimate matter, such as that of classical and quantum mechanics. The imbalance is due to the fact that conventional mathematics and related formulations are inapplicable for the treatment of biological systems for various reasons.
To begin, biological events, such as the growth of an organism, are irreversible. Therefore, any treatment of biological systems via reversible mathematics, physical and chemical formulations can indeed receive temporary academic acceptance, but cannot pass the test of time.
Quantum mechanics is ideally suited for the treatment of the structure of
the hydrogen atom or of crystals, namely systems that are fully reversible. These systems are represented by quantum mechanics as being ageless. Recall also that quantum mechanics is unable to treat deformations because of incompatibilities with basic formulations, such as the group of rotations. Therefore, the rigorous application of quantum mechanics to biological structures implies that all organisms from cells to humans are perfectly reversible, rigid and eternal.
Even after achieving the invariant formulation of irreversibility outlined in
the preceding section, it is easy to see that the underlying genomathematics remains insufficient for in depth treatment of biological systems. Recent studies conducted by Illert  have pointed out that the shape of sea shells can certainly be represented via conventional mathematics, such as the Euclidean geometry.
However, the latter is inapplicable for a representation of the growth in time of sea shells. Computer simulations have shown that the imposition to sea shell growth of conventional geometric axioms (e.g., those of the Euclidean or Riemannian geometries) causes the lack of proper growth, as expected, because said geometries are strictly reversible, while the growth of sea shells is strictly irreversible. The same studies by Illert  have indicated the need of a mathematics that is not only structurally irreversible, but also multi-dimensional. As an example, Illert achieved a satisfactory representation of sea shells via the doubling of the Euclidean reference axes, namely, a geometry which appears to be six-dimensional. A basic problem in accepting such a view is the lack of compatibility with our sensory perception. When holding sea shells in our hands, we can fully perceive their shape as well as their growth with our three Eustachian tubes. In particular, our senses are fully capable of perceiving deviations from the Euclidean space, as well as the possible presence of curvature. These occurrences pose a rather challenging problem, the achievement of
a representation of the complexity of biological systems via the most general possible mathematics that is:
(1) is structurally irreversible (as in the preceding section);
(2) can represent deformations;
(3) is invariant under the time evolution;
(4) is multi-dimensional; and, last but not least,
(5) is compatible with our sensory perception.
A search in the mathematical literature revealed that a mathematics verifying all the above five requirements did not exist and had to be constructed from the main features of biological systems.
As an example, in their current formulations hyperstructures lack a well defined left and right unit even under their weak equalities, they are not structurally irreversible, and they lack invariance. Consequently, they are not suitable for applications in biology.
After numerous trials and errors, a yet broader mathematics verifying the
above five conditions was identified by Santilli . it is today known under the name of Santilli hypermathematics; and it is characterized by the following hyperunits here expressed for the lifting of the Euclidean unit .
not posting the last one as an excuse for those arses but i think they allowed the math to be off on purpose as a failsafe as in litigation.... you know "service based industry with parts that break on time"
"chiral" is the (coat) left or right crystallography and i think it is the d isomer that the phages use for a coat to sneek by our immune guard... hell that gives them a damn nutriant clearance... . damn!
yeah they are evil and i hope we all live long enough to see these dogs in court.
Are you saying that established screening for trypanosomiasis,
protothecosis or for the presence of cyanobacteria simply will
not reveal anything since this pathogen was developed specifically
to avoid detection?
If so, and assuming we do go through the courts, how is anyone
to PROVE the existance of this pathogen to any party (lawyers,
scientists) willing to get involved?
TamTam, you have stated that the existence of the pathogen is
akin to a 'blue elephant in your garden' and this may well be the
case for you and perhaps for us but this particular blue elephant
is not so easily seen by others.
We seem to have a catch 22 situation unless we're able to raise
enough funds for initial research which would at least prove the
existence of SOMETHING before starting a legal battle.
TamTam, one more question if I may:
What do you think about the apparent links between this condition
and Lyme disease? Which comes first and paves the way for the other?
This is what I have been preaching for two months now, when I asked to get in touch w/ cliff, greema, South and release my information that I had researced. All about the Mitochondria.......Bloodline......neural interfaces.....but someone ganged up and decided that no, it's a bad idea b/c "I'm mentally crazy" Well, F.them. b/c it hasn't gotten there yet.
Crazy sounding post? Yeah, so. You think I give a care? HAHAHA
so back to mitochondra, Protein Kinases, yep......and guess where this can be found?
The toxins from the venom of the parasitoid wasp.
This is to the person that wrote to Skytroll and said talked of their reactions to the kinases......CAN YOU ELABORATE ANY PLEASE, I'M VERY INTERESTED.
WOW, HAVE WE ALL HAD THIS MACHINE MADE DISEASE FOR 5 YHEARS TODAY????? SHOULD I BE CELBRATING THE 5 YR ANNIVERSARY OF
ALL THE DUST THEY CREATED WHEN THE BOMBS BLEW UP THE WORLD TRADE CENTER....(OH, yeah, I know those airplanes that flew into the towers looked bad and all, but GD it, those steel structures were built to withstand the heat from a jet exploding.....you think some of us don't know this ?)
so, is this the 5 year anniversary? does this have something to do with the dust party they created?
As I wrote the other day......I THINK IT IS ODD....AN ARTICLE I RECENTLY READ SAID THAT THE INCREASE OF INSECT STINGS WILL RISE BY 40% INCREASE THIS FALL 06....hmmmmmm
AND THOSE DOP lABELS?...ALL F-ING PLANNED! B/C THEY NOT ONLY GOT OUR BLOODLINE MIXED/SCREWED UP, BUT THEY HAVE
PUT THE MAGNETIC PLASMAS TO WORK ON OUR MINDS......F YOU AND YOUR MAMMA TOO. I KNOW THE LIL INSECT, THE LIL FIBER, THE COLORS....I PERSONALLY AM FOND OF THE YELLOWS......HAHAHAHA
wake up screaming. vision is broken binary code.
Personality is but a multitude of delusions created
unknowingly to to fill that void.
a meaniningless march through the hives of STEEL and Concrete
The grammer of nothingness...........
HEED THIS GD IT.....THIS YOU HAVE GIVEN ME IS A HUMAN BARCODE SO YOUR NEW WORL ORDER CAN RUN AROUND......LET ME GUESS.....
IS DR VENTER OF NORDIC BLOOD? HMMMM WHO ELSE IS?
AND WHY ALL THE SPEECH PROBLEMS I SEE IN MY KIDS I TEACH TODAY? TELL ME WHY??????
AND.....WHO IS KERRY? I BET THE MAJORITY OF PEOPLE ARE NOT AWARE OF A COMPANY THAT IS CALLED....KERRY FOODS......hmmm....
SORRY, DON'T GET PISSY W. ME.......I DID NOT INFECT ANYONE.....BUT I WILL TELL YOU THIS.....I AM GOING TO SPIT ON EVERYTHING I SEE, JUST FOR YOU F-STICKS, GOT IT AHOLES?
AND JAN., I HEAR YOU ARE FLUENT IN SIGN LANGUAGE.....KNOW A LOT ABOUT DEAF EDUCATION, DO YOU NOT?
Last edited by London on Mon Sep 11, 2006 3:31 pm, edited 2 times in total.
The original Chagas Cruci, has a new name, according to American Health officials:
New Name (Pneumocystis jiroveci) for Pneumocystis from Humans [Stringer JR et al. Emerg Infect Dis 2002;8:891]: The genus Pneumocystis has been known for nearly 100 years. It was first reported by Chagas in 1909 who mistook it for Trypanosoma cruci, but was then established as a different organism and named Pneumocystis carinii. The organism was considered a protozoan until 1988 when DNA analysis showed it to be a fungus, but unusual because it lacked ergosterol and proved difficult to grow in vitro. The more recent name change is based on DNA analysis showing extensive sequence differences within the genus Pneumocystis species from different mammals. The new name is Pneumocystis jiroveci Frenkel 1999 (pronounced “jee row vet zee”) after the Czech parasitologist Otto Jirovec who described the organism in humans (Jeukaryot Microbiol 1999;46:89S
http://hopkins-abxguide.org/show_pages. ... ntent.html
SKY, FROM YOUR SITE I FOUND THIS:
IT LOOKS AS IF TAM TAM KNOWS SOME STUFF....THIS IS THE MEDICINE THAT HE RECOMMENDED...
A Double-Blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients [Bowden R et al. CID 2002;35:359]: The authors report a multicenter randomized, double-blind trial of Amphotec (ABCD) in a dose of 6 mg/kg/day vs. Amphotericin B in a dose of 1.0-1.5 mg/kg/day for treatment of invasive aspergillosis in 174 patients. The diagnosis was considered “proven” if there was a compatible clinical illness and detection of aspergillus by stain or culture from a normally sterile site, or proven with histopathology; it was “probable” if pulmonary with typical clinical and x-ray findings combined with two positive sputum cultures or a positive stain or culture from a BAL. Of the 174 participants, 88 were given ABCD and 86 were given Amphotericin B. Most of the patients had a hematologic malignancy (70%) and/or a bone marrow transplant (42%). Sites of infection included lungs in 66%, sinuses in 15%, and CNS in 7%. The 174 participants, 103 were considered evaluable. Of these, 8 (8%) had a complete response, 13 (13%) had a partial response (meaning a 50% or more improvement) and 32 (32%) were considered “stable” (defined as clinical improvement with less than a 50% improvement on x-ray). In terms of the comparison, the rate of “therapeutic response” with the endpoints noted above were similar, 52% in recipients of ABCD and 51% for recipients of Amphotericin B. Nephrotoxicity was greater in those receiving Amphotericin B (49% vs. 25%), but the rate of infusion-related side effects was greater in those who received ABCD. These results are summarized in the following table:
TAMTAM IS THIS ABOUT BARCODES.......LOOK, EITHER YOU KNOW SOMETHING AND ARE SCARED TO TELL US (WHICH I DOUBT) OR SOMETHING AWRY IS HAPPENING. WHY DON'T YOU TELL ME AND I WILL TELL EVERYONE....I DON'T GIVE A **** IF THEY COME KILL ME.
FOR YOU SEE, I'M ALREADY DYNG OF THEIR INFECTED BLOOD. TAMTAM, I LIKED THE MIXTURE OF THE CELLS.....VERY CLEVER WAS IT NOT? GIVE US SOME ANSWERS TAMTAM
People could appoint a location e.g Los Angeles, San Francisco, New York maybe London and unite in a club that is willing to put up a foundation and accept donations.
Goal could be to commission a company in the EU to screen the agent.
Results could be published online and will allow to identify the micro organism by any laboratory around the world.
Shotgun screening may also yield a blueprint about the species that are involved.
Test are always highly specific and standard tests stay negative so far I know.
The CBL (cyano bacterium like) micro organism can sometimes be detected in tissue. Its a yeast like body most resembling the etiological agent of paracoccidioidomycosis braziliensis and/ or lobomycosis.
Differential would include coccidioidomycosis. All above mentioned species are easily confused with other prototheca like micro organisms.
Next to this a series commensal resembling micro organisms are involved.
This would most associated with e.g synechocystis
To my knowledge there are no standard tests present for e.g protothecosis.
First unite, create a legal body and set well defined goals.
Last edited by tamtam on Sat Sep 23, 2006 8:42 pm, edited 2 times in total.
3. Shen Jin-chuan et al. Experiments on the Growth of Peanuts under Mind Control. Chinese Journal of Somatic Sciences (CJSC) V. 8, # 2, 1998, pp.51-60 (in Chinese)
4. Lee Si-chen et al. Revival of a Peanut by Psychokinesis. CJSC V. 9, # 2, 1999, pp.52-54 (in Chinese)
5. Shen Jin-chuan and Sun Chu-lin. Experimental Study Related to “Transfer Idea into Figure by Tienmu.” CJSC V. 10, # 2, 2000, pp.51-54 (in Chinese)
6. Shen Jin-chuan. Research of Ms. Sun Chu-lin’s Paranormal Function. Private letter of June, 2000, Unpublished (in English)
7. Ge Rong-chao et al. Study of the ATPase Activity of Fast -Germinating Sprouts of Wheat and Pea Treated [by Ms. Sun Chu-lin]. CJSC V. 8, # 4, 1998, pp.152-154 (in Chinese)
Last edited by Nadas Moksha on Mon Sep 11, 2006 6:00 pm, edited 1 time in total.
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