Login

|
|
mitochondrial inheritance questionsModerator: BioTeam
2 posts • Page 1 of 1
mitochondrial inheritance questionsInformation that pertains to questions below:
4 siblings (parents history unknown except that they were first cousins) all have hearing loss. All are married with unrelated spouses with no hearing loss. Oldest (Female) -has 4 female children with no hearing loss 2nd Oldest (Female) -has 2 male children with no hearing loss -1 female child with hearing loss 3rd sibling (Male) -2 male children and 1 female child with no hearing loss Youngest (Female) -3 male children and 1 female child all with hearing loss portion of the normal sequence of the tRNA gene: GCTTTGGGGGGTTC portion of the mutant sequence of the tRNA gene: GCTTTGGGGGGGTTC Question #1) Only one of the siblings (a female) had 100 percent mutant mitochondrial DNA. Based on the information above, which of the siblings had 100 percent mutant mitochondrial DNA? *I chose the youngest- because of how many offspring were affected ???? Question #2) Why do some of the female siblings with hearing loss have children who do not have hearing loss? (mutations in mitochondrial DNA are usually transmitted in a uniparental-maternal fashion in mammals) a: the females who had offspring without hearing loss were heteroplasmic b: there are two mitochondrial serine tRNA genes. The other tRNA gene sometimes compensates for the loss of function in the mutant tRNA gene. c: Biparental inheritance of mitochondrial DNA caused some of the offspring to escape hearing loss. d: those with hearing loss were segregational petites, whereas those without hearing loss were suppressional petites. *I chose d because the suppressional petites would account for no hearing loss?? Question #3) Which of the following is the most probable cause of this mutation? a: slippage during DNA replication b: tautomeric shift c: spontaneous deamination d: SOS mutagenesis *I chose a because that one seems to be the most likely cause Thanks in advance for your help!!
1) yeah, the youngest seem so
2) a could be true I don't know, what is the cause, so b could be true, theoretically too c could account as well, because some male mitochondria are transfered as well (but much less than female's;) http://www.biolib.cz/en/main/
Cis or trans? That's what matters.
2 posts • Page 1 of 1
Who is onlineUsers browsing this forum: No registered users and 0 guests |
© Biology-Online.org. All Rights Reserved. Register | Login | About Us | Contact Us | Link to Us | Disclaimer & Privacy