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siRNA

Genetics as it applies to evolution, molecular biology, and medical aspects.

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siRNA

Postby iri_black on Mon Jul 25, 2005 7:04 am

Can anyone tell what siRNA is? :(
I'm afraid I never heard of it :cry:

Thanks
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Postby opuntia on Mon Jul 25, 2005 3:45 pm

siRNA(Small interfering RNA) are a class of 20-25 nucleotide-long RNA molecules that interfere with the expression of genes.
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Postby iri_black on Mon Jul 25, 2005 4:08 pm

Thanks.
But can you tell me in what way? And what is the purpose?
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Postby zami'87. on Wed Jul 27, 2005 12:54 pm

iri_black wrote:Thanks.
But can you tell me in what way? And what is the purpose?

1. siRNA activate RISC(RNA induced silencing complex).
2.RISC binds to complementary transcript by base pairing between siRNA and mRNA.
3. mRNA is cleaved(degradation)=>gene silencing
purpose:gene regulation,antiviral defense...
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Postby mothorc on Thu Jul 28, 2005 5:31 am

Is there any different between siRNA and RNA antisense in molecule mechanism?
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