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myofibroblasts

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myofibroblasts

Postby kk » Tue Jan 05, 2010 1:22 pm

Is there a clear difference between fibroblasts and myofibroblasts?

As far as I am concerned, there are certain markers to identify myofibroblasts. I am sure some cells are permanently myofibroblasts (e.g. in the mammary gland?), but can a regular fibroblast trans-differentiate to myofibroblast upon certain signals (e.g. mechanical stress)? Does a regular fibroblast have nice stress fibers with all components or only myofibroblasts have alpha-smooth muscle actin as a component of their stress fibers?

Thank you in advance for any input. :wink:
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Postby kk » Tue Jan 12, 2010 9:27 am

Yes, an extensive answer can be found under the link below:

http://www.jbiomech.com/article/S0021-9290(09)00511-9/abstract
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