Biology-Online • View topic - COX-2 and PGE2

Join for Free!
122497 members

COX-2 and PGE2

Discussion of all aspects of cellular structure, physiology and communication.

Moderator: BioTeam

COX-2 and PGE2

Postby ezther » Thu Nov 26, 2009 7:32 pm

Hi All,

From what I understand, cyclo-oxygenase-2 (COX-2) is the enzyme for catalyzing the biosynthesis of prostaglandin E2, and hence the expression of the two entities are closely related. However, is anyone familiar with instances of when COX-2 and PGE2 have reciprocal expression?

Posts: 1
Joined: Thu Nov 26, 2009 7:29 pm

Postby JackBean » Fri Nov 27, 2009 2:02 am

First of all, PGE2 is not a protein, so it is not expressed.
There could be one way. If you massivelly upregulate the degrading enzyme, PGE2 should be deplenished and COX2 probably upregulated in response and vice versa, if you knock-out the degrading enzyme, PGE2 should accumulate and COX2 will be downregulated.

Cis or trans? That's what matters.
User avatar
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Return to Cell Biology

Who is online

Users browsing this forum: No registered users and 0 guests