COX-2 and PGE2

[ezther]

Hi All,

From what I understand, cyclo-oxygenase-2 (COX-2) is the enzyme for catalyzing the biosynthesis of prostaglandin E2, and hence the expression of the two entities are closely related. However, is anyone familiar with instances of when COX-2 and PGE2 have reciprocal expression?

Thanks!

[JackBean]

First of all, PGE2 is not a protein, so it is not expressed.
There could be one way. If you massivelly upregulate the degrading enzyme, PGE2 should be deplenished and COX2 probably upregulated in response and vice versa, if you knock-out the degrading enzyme, PGE2 should accumulate and COX2 will be downregulated.