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Cell Components after apoptosis/necrosis

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Cell Components after apoptosis/necrosis

Postby links0311 » Wed Nov 04, 2009 10:41 pm

I am familiar with the mechanism of apoptosis and necrosis, but what happens to the cellular components (DNA, proteins, lipids,..) afterwards is my question. I thought these components were collected and recycled into newly forming cells, but I don't know the mechanism or structure that does this collecting and where it delivers the cellular components to be reintegrated. Thanks for your time, and help would be greatly appreciated.

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Postby TheVirus » Wed Nov 04, 2009 11:38 pm

That's a really good question. I'm afraid i don't know. i'm just posting because i want to know too, and by posting its easier for me to know when someone else answers. Sorry.
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Postby JackBean » Thu Nov 05, 2009 4:55 am

With apoptosis are the cell components recycled (digested by the cell itself and recycled by another cells), with necrosis are the cell components released outside of the cell without any control, so the cleaning cells must do their work ;)
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Postby links0311 » Thu Nov 05, 2009 1:12 pm

Jack,

Thanks for the response. I am familiar with the process of apoptosis/necrosis. My question is how do the broken down cellular fragments (DNA, proteins, lipids) from these broken down cells make their way to into newly forming cells? What is the mechanism for this "recycling"?
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Postby TheVirus » Thu Nov 05, 2009 11:48 pm

And which are the "cleaning cells"? You mean phagocytes or other kind of white cell?
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Postby MrMistery » Fri Nov 06, 2009 12:40 am

in both cases debris are taken up by other cells through phagocytosis. in the case of apoptosis, neighboring cells take up the debris, and that is the end of the story. in the case of necrosis, specialized cells (like macrophages) are recruited to do the job, bringing on inflammation etc (the whole site becomes one big mess on the cellular level)
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Postby links0311 » Fri Nov 06, 2009 12:50 am

The question isn't related to phagocytosis itself, or apoptosis or necrosis. In my original post I asked what happend to the broken down DNA base pairs and other cellular debris after the cell has been broken down. Is there a recycling mechanism? I know some of these cellular components are reused, but I'm not sure how.
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Postby JackBean » Fri Nov 06, 2009 1:24 am

Yes, it is about phagocytosis. IF you want to reuse the cell parts, you must uptake them somehow, don't you? :roll:
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Postby links0311 » Fri Nov 06, 2009 2:13 am

My question isn't about the uptake process, it's about what happens after. Like I mentioned in my previous 2 posts, I am familiar with apoptosis, necrosis, and phagocytosis. My question stems from after these processes, focus on that, what happens to the cellular components that have been broken down by any of the mentioned processes? Are they carried by macrophages somewhere? How are they integrated into newly forming cells?
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Postby TheVirus » Fri Nov 06, 2009 2:41 am

They are integrated and used BY the macrophages and the other cells that do phagocytosis, they take up the debris and use it for their own development, and when they die other cells take them and so on. Right?
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Postby links0311 » Fri Nov 06, 2009 3:06 am

Virus I think you're on the right track. I believe there are 2 pathways for proteins. The first is they are taken up by lysosomes and degraded, the others travel to proteosomes and then the endoplasmic reticulum. In the ER usable substances are repackaged and recycled to the cell surface. Structures not moved to the cell surface are placed in vesicles called caveolae which are thought to be involved in the transfer of large molecules across endothelial cells, from the blood space to the tissue compartment. Thanks Virus, thats what I was looking for!
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Postby TheVirus » Fri Nov 06, 2009 3:30 am

Yeah...you're welcome. I got a little lost though, when you started explaining the two pathways of proteins, could you repeat that again, please? I got the idea, but i got a little dizzy with all the intracellular structures you mentioned. Could you explain that to me, please?
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