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Detoxification

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Detoxification

Postby andra » Wed Nov 04, 2009 1:56 am

Guys,as we know,detoxification is takes place in our liver,can u explain me how it works?and what are the enzyme take a part on this case?i hope u give me information from physiological point of view,thanx,
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Postby TheVirus » Wed Nov 04, 2009 2:11 am

What kind of detox do u mean? Drug detox? Alcohol detox? Metabolic detox?
”It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is the most adaptable to change.”
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Postby JackBean » Wed Nov 04, 2009 5:21 am

Basically, metabolism of xenobiotics has two phases
1) oxidation, usually done different CYPs
2) conjugation to different substances, this is done by some transferases
both steps should lead to increased polarity and thus solubility in water (=blood=urine)
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Postby JackBean » Wed Nov 04, 2009 1:23 pm

The conjugation can take place with UDP-glucuronate, PAPS to form sulphate, alkylation by S-adenosylmethionine or acylation by acetyl-CoA, conjugation with amino acids (Gly, Gln) or with GSH etc.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: Detoxification

Postby andra » Thu Nov 05, 2009 1:39 am

Thanx jack,well all of u,can u explain me about drug,alcohol,n drug detox?how does it work?detail,,please..thanx 4 ur help guys
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Postby JackBean » Thu Nov 05, 2009 5:13 am

Alcohol is oxidised to acetaldehyde and than probably to acetyl-CoA.
Drugs are like hundreds of types, so you must specify or read my previous posts ;)
http://www.biolib.cz/en/main/

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