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Please help! Question regarding microsatellite DNA.

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Please help! Question regarding microsatellite DNA.

Postby RoseLevin » Sun Oct 04, 2009 5:15 am

Which of the following is true for microsatellite loci?

a. are typically found in centromeres and telomeres
b. are typically made up of 1-4 bp repeat units
c. can be made up of tandemly arranged rRNA genes
d. can decrease in unit number during DNA replication
e. two of the above

I believe b is true...but can someone give me their opinion for d??
Thanks so much
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Postby MrMistery » Sun Oct 04, 2009 3:52 pm

i would have said d is false, as i thought they can only increase (like in fragile X syndrome). However, according to wikipedia they can also decrease in number http://en.wikipedia.org/wiki/Microsatellite_instability
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Postby RoseLevin » Sun Oct 04, 2009 4:20 pm

Ok...I thought that they could decrease. But I'm stuck on the wording...could it mean anything? Is there a difference between unit number and repeat number?
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Postby MrMistery » Mon Oct 05, 2009 3:30 am

i don't think so (though I am not an english native speaker, so wording is not my thing...).
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