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Folding of the insulin molecule

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Folding of the insulin molecule

Postby opuntia » Tue Jul 05, 2005 4:18 pm

Why does all human insulin molecules fold into the same shape?Is it because in all human insulin molecules the aminoacid sequence is the same so same kind of bonds occur within the protein chain or something else?
Last edited by opuntia on Tue Jul 05, 2005 5:07 pm, edited 1 time in total.
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Postby Chris4 » Tue Jul 05, 2005 5:02 pm

If its the same amino acid sequence then I would have thought it would fold in the same way. :?
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Postby MrMistery » Tue Jul 05, 2005 9:22 pm

Insulin is like any other protein. This goes for all proteins: if the aminoacid sequence is the same, the protein will always fold the same way. we do not exactly how this works, how each protein knows exactly how to fold.. not yet. If there are errors in translation or transcription than the protein will not fold correctly.

The body has many ways to identify and get rid of these errors, which are quite common. An example that comes to my mind is the PEST sequence, which, if exposed, has a complementarity with lysosoms, and the protein will be hidrolysed
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Postby victor » Thu Jul 07, 2005 5:30 am

Yup...lysosoms are like supervisors in our body...little mistake and hydrolysed.. :lol:
Just make it like this:
Example insulin protein have a chain: A-B-C-D-E (each of them is amino-acid)
To form that chain, our translation have to make the right amino-acids and bond it like the sequence above...(you can't make insulin if the sequence is like..A-C-B-E-D)
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Postby zami'87. » Fri Jul 08, 2005 12:10 pm

Yeah protein folding is really a mystery! A unique sequence of amino acids determs how polypeptide chain folds and protein function. And don’t forget hydrogen bonds between hydrogen atom of amino group and oxygen atom of the carboxyl group in another part of the chain. Also don’t forget S-S bridges in insulin(S from cysteine). Most proteins can spontaneously fold(shape depends of hidrophility of each aminoacid)And for more complex proteins of course don’t forget chaperones-proteins that help other complex proteins to fold propperly. Mutation of some chaperons can be lethal-eg HSP90 .
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