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XX and XY Chromosones-A Lost Girl seeks Answers

Genetics as it applies to evolution, molecular biology, and medical aspects.

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XX and XY Chromosones-A Lost Girl seeks Answers

Postby JimmyPamela » Wed Jun 24, 2009 2:34 pm

Will someone please tell me whether or not it is possible for a man to be born with both XX and XY Chromosones the result of which makes him feminine and want to be female since infancy. I believe that I possibly have XX Chromosones.
Thank you, and will someone please reply. JimmyPamela
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Postby biohazard » Thu Jun 25, 2009 7:41 am

One cannot really be born with "XX and XY chromosomes", because neither XX or XY are chromosomes, they are chromosome pairs.

However, one can be born with extra chromosome(s), e.g. they can have XXY, XYY, XXXY, XXX or some other such genotype. These cause different syndromes depending on the combination.

For example, XYY males are generally healthy, though have an increased risk of learning difficulties and score somewhat lower on IQ tests. Some other forms, such as XXYY and XXXY can cause more prominent syndromes, that include more difficult conditions including gynecomastia, feminine appearance and sometimes lower IQ scores among other problems. However, as far as I know, these conditions are not related to a person's desire to be a female rather than a male.

Vast majority of the men who feel they are women (and the other way round) have normal XY chromosome pairing, but may have some other genetic features that make them susceptible to transgenderism or whatever it is called nowadays.

But in brief, XYY males and XXX women are usually healthy and "normal", most of them (or their parents, friends and doctors) don't even know they have this extra chromosome and it does not really affect their everyday lives. When the chromosomal abnormalities become more prominent, there will usually be more problematic outcomes.
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Postby biohazard » Thu Jun 25, 2009 10:52 am

Oh, and in case you want to know your own situation, sex chromosomes can be easily analysed by a medical cell biologist, for example.

A simple blood test is required, and the lymphocytes are stained and analysed visually. An X and Y specific stains / probes indicate whether there is an extra set of chromosomes or other such "apparent" anomalities in the genome. This does not reveal genetic duplications or mutations, which require their own probes and more sophisticated methods of analysis.
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Re: XX and XY Chromosones-A Lost Girl seeks Answers

Postby Jesse2504 » Fri Jun 26, 2009 9:59 am

I think this is more psychology than biology. Feeling feminine can often be a need for affection, beauty, acceptance or friendship which males usually portray as "silly mushy crap" and it can get people down a lot.

Recapping what was said before, if you have a genetic abnormality you would have a lot more wrong than just feelings.
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Postby biohazard » Fri Jun 26, 2009 1:33 pm

Well, that depends on the genetic abnormality in question: like I said most of the XXX and XYY genotypes are pretty much normal despite this seemingly gross genetic abnormality. Then again, a simple point mutation in the right place can make one's life a living hell. Like so often with biological systems, it is usually a sum of many factors and I wouldn't be surprised if there was a genetic element behind transgenderism (or just "feeling feminine") in many cases.
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Postby CLOVIS » Wed Oct 14, 2009 2:40 pm

To note on the above comments, The third X chromosome in XXX is not a healthy or stable pair. Actually, this pair shows feministic qualities and is mentally unstable. These women usually were locked up in hospitals. The XXY chromosome pair is more stable to have than XXX, but later developes the feministic qualities of a female later in life.
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Postby biohazard » Thu Oct 15, 2009 6:54 am

You over-generalize now. Persons with these chomosomes can be "normal", meaning that they fit the society pretty much as anyone else and many of these cases may even go undiagnosed. Of course, they have a bigger chance of having certain problems, but that does not mean they always do.
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