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hypoxia with CoCl2

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hypoxia with CoCl2

Postby matjes » Fri Jun 12, 2009 10:30 am

Hi,
I'm searching for my bachelor thesis the reaction of CoCl2 with O2 when it's used in hypoxia experiments. I can't find anything specific.
Maybe you have also a reference to this?

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Postby Hypoxia » Fri Sep 23, 2011 8:01 pm

Sorry to bump this old thread but does anyone have any idea on this? I'm also interested on mimetics in general and possible noisy data?
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Re: hypoxia with CoCl2

Postby aptitude » Mon Oct 10, 2011 3:35 am

From http://toxsci.oxfordjournals.org/content/82/2/638.full:

"Cobalt has been widely used in the treatment of anemia and as a hypoxia mimic in cell culture and it is known to activate hypoxic signaling by stabilizing the hypoxia inducible transcription factor 1α (HIF1α)."
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