Login

Join for Free!
118823 members


Inhibition of enzyme - will it result in upregulation?

Discussion of all aspects of cellular structure, physiology and communication.

Moderator: BioTeam

Inhibition of enzyme - will it result in upregulation?

Postby Jamus » Sat Apr 25, 2009 12:49 pm

Hey all,
I am trying to figure out a mystery here. In an experiment that I've done a few weeks ago, ketoconazole (CYP inhibitor) seems to result in an overall increase in the quantity of the CYP 450 proteins in the liver. I can understand how this works if it is a CYP inducer, but... can an inhibitor have such a profound effect that the cell attempts to compensate for the loss in the ability to metabolise substances that it upregulates the synthesis of the CYP?

I've been googling for the past few hours, but nothing solid has come up :(
Jamus
Garter
Garter
 
Posts: 9
Joined: Mon Dec 08, 2008 8:01 am

Return to Cell Biology

Who is online

Users browsing this forum: No registered users and 1 guest