Login

Join for Free!
118902 members


cAMP as second messenger in GPCR signal transduction

Discussion of all aspects of cellular structure, physiology and communication.

Moderator: BioTeam

cAMP as second messenger in GPCR signal transduction

Postby hplc » Sun Feb 15, 2009 12:31 pm

Hello.

I'm currently reading about the signal transduction from G protein-coupled receptors in relation to the cAMP second messenger. But after this chapter, in every example of signal transduction, the book uses cAMP as a second messenger and activator of protein kinase A. They do this for the rest of the book. Not only in the chapter I'm currently reading.

Does this mean that cAMP is the only sencond messenger we have, or is it used only in GPCR signal transduction? Or how does it work?

Thank you.
hplc
Garter
Garter
 
Posts: 9
Joined: Thu Sep 04, 2008 1:10 pm

Postby MrMistery » Sun Feb 15, 2009 4:13 pm

cAMP is definitely not the only second messenger we have. other examples include cGMP and Calcium ions.
And no, GPCRs do relay the message solely through cAMP, they can, as I remember, activate phospholipase C and guanynyl cyclase as well.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter
User avatar
MrMistery
Inland Taipan
Inland Taipan
 
Posts: 6832
Joined: Thu Mar 03, 2005 10:18 pm
Location: Romania(small and unimportant country)

Re: cAMP as second messenger in GPCR signal transduction

Postby hplc » Mon Feb 16, 2009 7:09 pm

Thank you very much for your help.
hplc
Garter
Garter
 
Posts: 9
Joined: Thu Sep 04, 2008 1:10 pm


Re: cAMP as second messenger in GPCR signal transduction

Postby addisongrace22 » Wed Oct 07, 2009 7:31 pm

thanks for such a good in depth explaination of second messengers. :D
addisongrace22
Garter
Garter
 
Posts: 2
Joined: Wed Oct 07, 2009 7:09 pm


Return to Cell Biology

Who is online

Users browsing this forum: No registered users and 2 guests