The Living Cell

[Conger]

I have three questions.

1. How do voltage-sensitive channel proteins respond to electrical signals?

2. How do receptor proteins pass information into cells?

3. Why are protein markers important in matching organ donors to recipients?

[mith]

What do you know about marker proteins?

[Dr.Stein]

Protein marker... maybe it is MHC molecule that present specific peptide...? If it is so, it is important to recognize whether it is a self cell or nonself cell, means that if the graft is recognized as nonself by immune system of the donor, the organ will be rejected (result in graft-versus-host-disease or GVHD), whereas if the graft is recognized as self it will be accepted (the transplantation is successful).

[sdekivit]

I have three questions.

1. How do voltage-sensitive channel proteins respond to electrical signals?

2. How do receptor proteins pass information into cells?

3. Why are protein markers important in matching organ donors to recipients?

voltage dependant channel proteins open/close at a specific memrane potential. When the potential exceeds the trigger value the channel responds.

Receptor proteins can pass information into the cell by using for example signal molecules like cAMP and so on.This triggers certain proteins in the cell.

MHC presents pieces of an protein because it is 9in contact with a proteosome that cuts the proteins. The immune system may recgonize the piece of protein as bad while it is infact another cut of the same protein that is not basd at all.

[Dr.Stein]

Receptor proteins can pass information into the cell by using for example signal molecules like cAMP and so on.This triggers certain proteins in the cell.

Yep, the second messenger

[sdekivit]

Receptor proteins can pass information into the cell by using for example signal molecules like cAMP and so on.This triggers certain proteins in the cell.

Yep, the second messenger

i LOVE molecular signaling pathways

[Dr.Stein]

ITIM & ITAM motifs yeah

[lollipop29]

Hey,

im writing something up on the activation of genes by extra-cellular signalling molecules. some of these molecules are growth factors right? i no they bind to tyrosine-kinase receptors on the cell surface but what about G-protein receptors or ligand ion gated channels? these aswell?