Prednisone stimulates Th1 but enhances th2 when discontinued

[hullcrush]

Prednisone blocks il-4 and il-10 thus increasing interferon gamma, an integral part of th1.
But after it is discontinued, the il-4 and il-10 are worse than before the prednisone was started. Why is this?

[rodregez]

Yes there is an interaction beetween prednisone and the interleukin,
see here : http://cat.inist.fr/?aModele=afficheN&cpsidt=1722746