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Prednisone stimulates Th1 but enhances th2 when discontinued

Human Anatomy, Physiology, and Medicine. Anything human!

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Prednisone stimulates Th1 but enhances th2 when discontinued

Postby hullcrush » Sun Nov 02, 2008 4:16 am

Prednisone blocks il-4 and il-10 thus increasing interferon gamma, an integral part of th1.
But after it is discontinued, the il-4 and il-10 are worse than before the prednisone was started. Why is this?
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Re: Prednisone stimulates Th1 but enhances th2 when discontinued

Postby rodregez » Wed Apr 22, 2009 1:30 pm

Yes there is an interaction beetween prednisone and the interleukin,
see here : http://cat.inist.fr/?aModele=afficheN&cpsidt=1722746
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