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why nucleus is said to be acid

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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why nucleus is said to be acid

Postby mageshkov » Sat Aug 02, 2008 10:17 am

i do have doubt why nucleus is said to be acidic
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Postby MisterATP » Sat Aug 02, 2008 12:03 pm

It is because of DNA (hence it is acid!)
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Re: why nucleus is said to be acid

Postby MikeS » Fri Aug 15, 2008 11:58 pm

Good question, I was once puzzled by it too. I always thought DNA contained nitrogenous bases, which are obviously basic. But why are they acidic?

I think the reason is in the phosphate groups. The ATGCs are basic, the (deoxy)ribose are sugers, hence neutral. But the phosphate groups are acidic. This is why when you store DNA, you store them as their salt form, which can be considered the conjugate base of DNA.

A detailed, graphical explanation is available here
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