database of small molecule and receptor targets

[simplitia]

Dear all:
I am wondering if there is a database/index that has a list of molecules and their receptor targets? Basically it would look something like:
drug123 targets gene345

thanks and advance!

Alex

[dipjyoti]

May be these link can help you.
http://www.jbc.org/cgi/content/abstract/276/41/37787
http://www.pubmedcentral.nih.gov/articl ... id=1748251
http://www.simbiosys.ca/ehits_lasso/LAS ... Spider.pdf

[Istria]

http://search.vadlo.com/b/q?sn=15862179 ... gand&rel=3
http://search.vadlo.com/b/q?sn=15862179 ... e%22&rel=3
http://search.vadlo.com/b/q?sn=15862179 ... rget&rel=3

[pdavis68]

I'm not aware of any general database for this. It's simply too large a subject for a generalized database to be useful.

The way most people, I believe, determine this information is in looking at a specific target or looking at a specific small molecule.

For example, for drugs, pretty much any serious pharmacology text will tell you what the targets are for those drugs.

On the other hand, if you want to look at targets, it's generally easy to find ligands for them.

Wikipedia is actually a really good place to get started. For example, want to know what ligands target the adrenergic receptors? Simply look it up in wikipedia: http://en.wikipedia.org/wiki/Adrenergic_receptors#Comparison

The problem is, from a usefulness point of view, a generalized database, like what you're asking for, is of limited use. Most people are looking for targets of a specific molecule or ligands for a specific target.

Are you looking for anything in particular?

[Pratap]

Hi.. i have seen your query today... To my knowledge, there is a product called NetPro which provide manually curated small molecule-protein interactions. They have more that 50K unique small molecules covering more than 100K interactions. Quite reliable.

Pratap

[ainala8055]

Datbases such as DrugBank database,Cambridge database