Two models of Enzyme-Substrate binding

[shobber]

Here is a question: What's the merit of the "Induced-fit model" over the "Lock and Key model" regarding enzyme and substrate binding?

[mith]

lock and key assumes substrate/enzyme are rigid. That means it's easier to calculate docking if you're doing it computationally.

[MrMistery]

induced fit is more close to reality. if you're learning it theoretically, it's the "right" one.
lock and key is a reduction, but it is easier to work with.