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About Pop. genetic heterozygosity & HWE

Genetics as it applies to evolution, molecular biology, and medical aspects.

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About Pop. genetic heterozygosity & HWE

Postby Proteinic » Tue May 06, 2008 3:41 pm

Hi friends
First of all, sorry about my English it is not so fluent
I want to be an active member in this forum and also to make a friendships with other members
I am a student fourth year Zoology science and I am so interested in population genetic and bioinformatics
I read a lot of scientific articles in Population genetic and i,ve alot of questions about them
all most all of the methodology used in these researches depends on genotyping protein polymorphism or DNA for finding allele frequency, calculating heterozygosity and, estimating genetic variability Chi square and estimating the Hardy-Weinberg equilibrium HWE
What I couldn’t understand is the interpretation for the result, it always seems to be ambiguous and sometime with no meaning
For example something like heterozygosity or allele fre. what kind of things can informs us about the population
Yes I read that these are evolutionary parameters, by which we can know the selection pressure or genetic drift but if we have for example a heterozygosity 23% what can tell us about selection or about genetic drift? and also the same thing about HWE
How can read these figures ?
Could anyone summarize the use of these parameters in a simple way

And, I have an other question if we prove that a loci or a gene is in Hardy-Weinberg equilibrium HWE, does this mean that this gene cannot be used as a genetic marker or there is no hope for this Loci to be in Linkage-disequilibrium with any other gene

i think this is enough for now
if anyone have a question i also fully ready to answer him (if i know)
Proteinic
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Postby Proteinic » Fri May 09, 2008 5:49 pm

Hi
It seems that not so many people here interested in Population genetic anyway I have an other question
Who know what does effective alleles mean?
Proteinic
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Re:

Postby F4T32008 » Sun May 11, 2008 4:23 pm

Proteinic wrote:Hi
It seems that not so many people here interested in Population genetic anyway I have an other question
Who know what does effective alleles mean?


Maybe effective alleles are the alleles which contain the genes to be inherited to the next generation.
But I'm not too sure about it..

And, I have an other question if we prove that a loci or a gene is in Hardy-Weinberg equilibrium HWE, does this mean that this gene cannot be used as a genetic marker or there is no hope for this Loci to be in Linkage-disequilibrium with any other gene
Maybe the gene can be in a linkage.. But does HW said that all of the population must be in the same way? I mean the number of the linkage for a population is the same with another?
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Postby Proteinic » Tue May 13, 2008 7:34 pm

Thanks F4T32008 for answering my question I think your answer is oky

As I know or understand the link-disequilibrium stats that for tow loci Q and A to be Linked
There should be a disequilibrium in their frequency according to each other (if I am wrong plz say so)
But what about the the disequilibrium between the observed A and the expected A is that effect the linkage between A and Q
I want to exchange books with other and I have so many great books
Such as
Gene targeting protocols
Analysis of Genes and Genomes.pdf
Bioinformatics-A Practical Guide to the Analysis of Genes and Proteins Second Edition .pdf
Cell Separation-Methods and Applications.pdf
coilsprg.pdf
Color Atlas of Genetics.pdf
Current Protocols in Bioinformatics.pdf
Current Topics in Computational Molecular Biology.pdf
PCR Cloning Protocols.pdf


So if anyone interested just send an email to this email photonoman@hotmail.com
And plz write in the title “Book request”
Proteinic
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Re:

Postby F4T32008 » Sun May 18, 2008 3:53 pm

[quote="Proteinic"]

As I know or understand the link-disequilibrium stats that for tow loci Q and A to be Linked
There should be a disequilibrium in their frequency according to each other (if I am wrong plz say so)
But what about the the disequilibrium between the observed A and the expected A is that effect the linkage between A and Q

Yes, you're right. as I know, once linkage or crossing-over happened in the chromosomes..
It will result in a disequilibrium of the population.
So, I think, the HW equilibrium cannot be used as a calculation in a population..

Because a lot of mutation happened right now..
So, the equilibrium state is very hard to come true..

That's all about my opinion :D
F4T32008
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