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Isoleucine anti-codons

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Isoleucine anti-codons

Postby maingroupe » Tue Mar 11, 2008 11:14 pm

hello people i have a simple question. why can't UAU be an anti-codon for Isoleucine.

Isoleuine codons: AUU AUC AUA
Isoleuine anti-codons: UAA, UAG, UAI

thanks
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Postby MrMistery » Wed Mar 12, 2008 12:14 pm

In can in theory. But I can pair with either C, U or A(wobble). So you see, UAI can pair with no problems with all three codons. I have never heard of the absence of the UAU anticodon, but then again, i don't know them all by heart. But because UAI is present, the absence of UAU would not pose a problem.
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Postby Cat » Wed Mar 12, 2008 1:42 pm

My guess would be because G-U base pairing is permitted in translation and UAU would be able to bind Met (AUG) as well as Ile (AUA) thus creating a problem while UAI can bind all three Ile codons, but not Met.
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Postby MrMistery » Wed Mar 12, 2008 1:57 pm

Good point. Didn't think of that..
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