Human Anatomy, Physiology, and Medicine. Anything human!
ok got ya.. lol as you can tell i am no biologist, but i did read the comments and i understand her story a bit more and how it is remarkable how her body reacted to her transplant, i wonder if she experienced g.v.f.d.. i dont wish that on anyone i had it to something like 90% of my body and it was horrible i was like a scaly sore fish yuk.
Anyway i do have a question or few that i hope you can answer. When i was diagnosed both times my chromosomes where not the 'normal' 23 pairs i actually had 92 so i was diagnosed with A.L.L with near tetraploid which really decreased my chances of survival down to 20% from 75%. My question is was i born with near tetraploid chromosones? Does having the stem cell transplant fix my chromosones? I have read up on it and read bout disfigurements and metal problems that is associated with it thats if they baby survives after birth or isnt a miscarriage but i dont understand why i am fine, i have no metal issuse, i am completely normal. I did read that a sign of tetraploid is a beaked nose which i have, and at birth and club foot is present, i was born with a turned foot which is fine now, but apart from those physical signs i have nothing.
Oh other thing i was told i ll never be able to have kids and have irreversible infertility after my transplant due to the radiotherapy which apparently 'fried' my ovaries, and wth the combination of powerful chemo, well i proved the docs wrong i have a 5 yr old daughter so i just wondering its my chromosone problem hereditary?
the heredity depends on whether the tetraploid cells are all in your body or whether they are just curiosity in some part of your body. Were you diagnosed with tetraploidy before or after chemo? I would guess after, right? So it migth be caused by the chemo, but that won't change all cells in your body. However, if your ovaries were supposed to be hit by the chemo, they may have tetraploidy and thus your eggs would be diploid. In consequence, your children would be triploid and thus sterile. But that is only imaginary hypothesis! You need to have your daughter tested.
Cis or trans? That's what matters.
I am looking at my medical files right now that were from the 1st time i was sick and i can tell you this is straight from the files: She has ALL with tetraploidy. Chromosome analysis showed 2 near tetraploid clones.
This is after i had a relapse: Chromosome analysis of the marrow was difficult due to few metaphases being present but 2 hyperdiploid metaphases were seen which almost certainly represent the near tetraploid clone seen at diagnoses.
Hope this helps
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