Login

Join for Free!
112389 members


Recent discovery in stem cell research.

Human Anatomy, Physiology, and Medicine. Anything human!

Moderator: BioTeam

Postby mcar » Sat Nov 24, 2007 2:55 pm

Ethical dilemma is always a point of discussion.
What is the purpose of the research?
-simply to alleviate human suffering from diseases. Most specially the focus is on the replacement of damaged cells and organs. We just need to see where are we going to put ourselves here. Catholic or any religious concerns may criticize such. But the point is, are we in or out of the objectives of the research. It could be quite lucrative for experts, but we can't play God.
---Just one act of random kindness at a time and you can change the world---
mcar
Coral
Coral
 
Posts: 493
Joined: Fri May 27, 2005 8:58 am
Location: Pilipinas a.k.a. Three Stars and a Sun (300, 000 sq Km)

Postby alextemplet » Sat Nov 24, 2007 10:53 pm

You raise a good point, mcar, and obviously if this is possible, then the ethical debate will have to take place on whether or not it should be done. However, before we all get up in arms over that, I think we should first determine whether or not it can be done at all; otherwise we'll end up in an argument over whether or not we should do something that can't be done anyway. Rather silly, in my humble opinion.
Generally speaking, the more people talk about "being saved," the further away they actually are from true salvation.

~Alex
#2 Total Post Count
User avatar
alextemplet
King Cobra
King Cobra
 
Posts: 5599
Joined: Fri Dec 23, 2005 4:50 pm
Location: South Louisiana (aka Cajun Country)

Postby mith » Sat Nov 24, 2007 11:39 pm

You plan for the future so that you don't have to deal with a monstrosity that may be generated because you didn't believe it possible.
Living one day at a time;
Enjoying one moment at a time;
Accepting hardships as the pathway to peace;
~Niebuhr
User avatar
mith
Inland Taipan
Inland Taipan
 
Posts: 5345
Joined: Thu Jan 20, 2005 8:14 pm
Location: Nashville, TN


Postby alextemplet » Sun Nov 25, 2007 5:50 am

mith wrote:You plan for the future so that you don't have to deal with a monstrosity that may be generated because you didn't believe it possible.


Yes, that would be very wise as well.
Generally speaking, the more people talk about "being saved," the further away they actually are from true salvation.

~Alex
#2 Total Post Count
User avatar
alextemplet
King Cobra
King Cobra
 
Posts: 5599
Joined: Fri Dec 23, 2005 4:50 pm
Location: South Louisiana (aka Cajun Country)

Postby mith » Mon Nov 26, 2007 11:26 pm

I was able to read a copy of the Cell article(courtesy of one of my Profs)

Couple of interesting things to note

1. They grew a cell culture using skin cells from a 36 year old female. The viral vector treatment was performed and the cells were cultured.

There were at least two types of cells found. The researchers picked out the hES cells based on morphology(flattened) but there were also some "granulated" colonies that they were unable to identify. In fact the granulated cell colonies outnumber the hES-like cells 10:1.

2. Among the 32k genes analyzed:

The iPS cells had 5k genes which showed a 5 fold difference in expression compared to normal skin cells. Comparatively, an embryonic stem cell shows 6k genes with 5 fold differences.

Comparing iPS and hES, 1267 genes showed 5 fold differences.

3. To test pluripotency, they injected the cells in to irradiated mice. Tumors formed consisting of various tissues-gut, cartilage, neural, muscle.

4. 20% of mice derived from iPS cells developed tumors, attributable in part to one of the retroviral genes.
Living one day at a time;
Enjoying one moment at a time;
Accepting hardships as the pathway to peace;
~Niebuhr
User avatar
mith
Inland Taipan
Inland Taipan
 
Posts: 5345
Joined: Thu Jan 20, 2005 8:14 pm
Location: Nashville, TN

Postby alextemplet » Tue Nov 27, 2007 2:16 am

So it appears that this technology currently has too high a risk of cancer to be feasible as a medical treatment at this time. Does this apply to stem cell therapy in general or only to this exact method?
Generally speaking, the more people talk about "being saved," the further away they actually are from true salvation.

~Alex
#2 Total Post Count
User avatar
alextemplet
King Cobra
King Cobra
 
Posts: 5599
Joined: Fri Dec 23, 2005 4:50 pm
Location: South Louisiana (aka Cajun Country)

Postby mith » Tue Nov 27, 2007 2:23 am

Well you have to know that this method involves insertion of 4 genes including one that is associated with tumor cells. If you do it without the tumor gene, the success rates are much lower. Another problem is that the tumor gene integrates pretty much randomly(needs better targeting) in around 20 different spots. So yes, it is only in this method right now, but I don't think it's inherently a design flaw, more like a technical obstacle.
Living one day at a time;
Enjoying one moment at a time;
Accepting hardships as the pathway to peace;
~Niebuhr
User avatar
mith
Inland Taipan
Inland Taipan
 
Posts: 5345
Joined: Thu Jan 20, 2005 8:14 pm
Location: Nashville, TN

Postby alextemplet » Tue Nov 27, 2007 2:34 am

I see. So given time for research and development, this might lead to a useful form of therapy.
Generally speaking, the more people talk about "being saved," the further away they actually are from true salvation.

~Alex
#2 Total Post Count
User avatar
alextemplet
King Cobra
King Cobra
 
Posts: 5599
Joined: Fri Dec 23, 2005 4:50 pm
Location: South Louisiana (aka Cajun Country)

Previous

Return to Human Biology

Who is online

Users browsing this forum: No registered users and 2 guests

cron