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TMPT

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Postby kikkid » Sun Oct 14, 2007 12:10 am

Can anyone tell me if thiopurine S-methyltransferase (TPMT) codes for the protein thiopurine methyltransferase?
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Postby blcr11 » Sun Oct 14, 2007 7:37 am

They are the same enzyme. See http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/1/1/67.html
There is another enzyme, EC 2.1.1.9 with a similar name, but it has a broader range of thiol acceptors compared to EC 2.1.1.67 (TPMT). You can check out this kind of information from either the Enzyme Commission web site, or the Expasy or NCBI servers.
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Postby MrMistery » Sun Oct 14, 2007 11:17 am

nice answer blcr :shock: :shock:
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Postby kikkid » Sun Oct 14, 2007 3:42 pm

I am a bit confused. I am doing a research project. I was given a section of DNA, and identified the gene as Thiopurine S-methyltransferase, which I know is also known as EC 2.1.1.67 or Thiopurine methyltransferase. I was then asked what protein it codes for. Is it correct to say that TPMT codes for the enzyme Thiopurine S-methyltransferase?
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Postby blcr11 » Mon Oct 15, 2007 12:19 am

I’m not sure what the problem is, exactly. The DNA sequence doesn’t have a different name distinct from the name of the expressed protein. For example, if I clone the gene for lysozyme, I can refer to either the DNA sequence or the expressed protein as “lysozyme”, though, I suppose, I would talk about the ‘DNA sequence of lysozyme’ if I had to make a distinction that wasn’t clear from the context. There are, I think, four names for TPMT that different people have used. Any or all of them could be used to refer to the DNA sequence. You could refer to the accessention number of the DNA sequence if you want, but there can be several such numbers for the same sequence. The accessention number only identifies the sequence within a particular database. I don’t know that there’s anything wrong in saying the TPMT gene expresses Thiopurine methyl transferase.
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