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protein specificity

Genetics as it applies to evolution, molecular biology, and medical aspects.

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protein specificity

Postby stone » Thu May 17, 2007 2:09 am

can somebody explain me the differences between protein specificity and protein affinity ?

thanks
stone
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Postby blcr11 » Thu May 17, 2007 1:30 pm

I'm not sure I have the best answer or not. In my mind the two can be related. Specificity would be a discriminatory function--an enzyme can discriminate between two stereoisomers of a substrate and so is specific, preferring to use one isomer over the other. Affinity would refer to binding energy; a more favorable free energy of binding implies a greater affinity for the substrate or other protein (in the case of protein-protein interactions, for example). It may sometimes be true that higher affinity implies greater specificity, but that need not be the case--it is possible to show high selectivity without high affinity, for example.
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