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topical steroids

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topical steroids

Postby Cotton King » Wed Apr 04, 2007 9:19 am

Is it possible to become 'resistant' or 'immune' to topical steroids eg hydrocortisone used for eczema? As in will their effectiveness decrease with usage?
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Postby Revenged » Wed Apr 04, 2007 9:46 am

you won't become 'immune' to cortisol as it is naturally produced in the body... and i'm unsure of how effective they are supposed to be... they never worked for me...
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Postby Dr.Stein » Wed Apr 04, 2007 10:08 am

I am not sure but it might be Langerhans cells digest them before it takes effect :?
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Postby canalon » Wed Apr 04, 2007 7:42 pm

Dr.Stein wrote:I am not sure but it might be Langerhans cells digest them before it takes effect :?


Topical means applied on the skin DrStein They are not likely to be digested. As for an attenuation of the effects of such creams over time, I have no idea if it is likely or how it would work. sorry.
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Postby Dr.Stein » Thu Apr 05, 2007 2:51 am

Grrr I know that :evil:
What I was going to say is that Langerhans cells that locate in subcutaneous tissue will encounter the cortisol and perform phagocytosis (=intracellular digestion) towards it before it diffuses into any cappilaries :roll:

This also provides explanation for people who suffer inflammation and also allergy after applying such cream. It's because the barrier immune system (Langerhans cells) works to attack the cream.

I hope this makes sense :?
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Postby crashxxbrn » Wed Apr 25, 2007 12:36 am

Hydrocortisone is pretty weak compared to other steroids, like prednisone and dexamethasone (for comparison's sake, hydrocortisone is about a fourth of the strength of prednisone, and dexamethasone is around 50x as potent). There are also topical immunomodulators (Protopic and Elidel) out there for eczema; definitely worth looking into if this question is about yourself.

But no, you don't become immune to it. The skin inflammation can become so severe that hydrocortisone becomes ineffective, though.
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