Login

Join for Free!
116979 members


URGENT I Need Help!!! Re: leukocytes

Human Anatomy, Physiology, and Medicine. Anything human!

Moderator: BioTeam

URGENT I Need Help!!! Re: leukocytes

Postby dogsrus » Fri Mar 30, 2007 1:03 am

I am in an A&P class and it has been 10 yrs since I have taken the Biology. In the refresher portion of this class I was given a question to answer and not sure if what I am finding is what I really need to look for.

Q: What type of transport would be used by leukocytes when they secrete toxic substances and enzymes on to the surface of parasitic worms in humans?
dogsrus
Garter
Garter
 
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm

Postby Dr.Stein » Fri Mar 30, 2007 2:13 am

Large parasites, such as worms, cannot be ingested by phagocytes; however, when the worm is coated with antibody, especially IgE, eosinophils can attack it through their binding to the high-affinity Fc-epsilon-RI. Similar attacks can be mounted by other Fc receptor-bearing cells on various large targets. These cells will release toxic contents of their granules directly onto the target, a process known as exocytosis.

Example:

Image
Eosinophils attacking a schistosome larva.
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby Darby » Fri Mar 30, 2007 2:42 am

Definitely exocytosis - are you studying golgi function?
Darby
Viper
Viper
 
Posts: 1262
Joined: Thu Mar 02, 2006 5:29 pm
Location: New York, USA


Postby dogsrus » Fri Mar 30, 2007 3:54 am

No, I am not studing anything specific, the teacher has about 28 questions for General Biology review and has assigned people to each question. Unfortunately, like I said before it has been 10 yrs since I have even looked at anything relating to biology. Is eosinophils or exocytosis the transport system or is it the toxin that is released? I read that Hemolysin which is produced by E-coli has a cytotoxic affect on leukocytes.
dogsrus
Garter
Garter
 
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm

Postby Dr.Stein » Fri Mar 30, 2007 6:16 am

Your words made me confused :roll: Or you don't understand the terms here :?

Eosinophils releases toxin, the mechanism of this toxin releasing is called exocytosis.
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby Revenged » Fri Mar 30, 2007 10:25 am

eosinophil is the name of the type of white blood cell that targets worms...

the antibody produced is IgE... IgE binds to the worm...

(where does the IgE come from - i'm not sure...)

the white blood cell can recognise the IgE on the worm and then it can releases 'toxin'...

exocytosis is just a way that the toxin moves out of the cell... and this is what the question is asking about...

http://academic.brooklyn.cuny.edu/biolo ... /exocy.htm

NB. E-coli is a bacteria... It is not relavent to your question about exocytosis/destroying worms...

Hope that helps...
User avatar
Revenged
Coral
Coral
 
Posts: 118
Joined: Sat Oct 07, 2006 10:27 pm

Postby dogsrus » Sat Mar 31, 2007 2:41 am

thank you all for your help, i have a liitle better understanding. :)
dogsrus
Garter
Garter
 
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm


Return to Human Biology

Who is online

Users browsing this forum: No registered users and 0 guests

cron