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Unknown disease in Malaysia,1 of my friend infected.Pls Help

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Postby Revenged » Sun Apr 01, 2007 11:09 am

Darby wrote:- fat cells. These tend to keep a "base level" of estrogen in the body. Women who are anorexic, or abnormally thin for other reasons, can have problems related to too-low estrogen levels. Usually the effects are reproductive; other effects from lowered estrogen seem to be suspected but not clearly understood, from what I can find in a quick search.


Interesting... I didn't know that...

So really obese people are infertile because they have such high oestrogen levels because they have so much fat???
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Postby Darby » Sun Apr 01, 2007 1:15 pm

Are obese people infertile?
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Postby Revenged » Sun Apr 01, 2007 3:12 pm

Darby wrote:Are obese people infertile?


Obesity can cause menstrual problems and if it severe it can cause you to completely stop ovulating causing infertility... I don't know why this occurs but from what you are saying, i guess it can be explained by high oestrogen levels produced from fat cells...

There may be a link between PCOS and obesity, which can also lead to infertility due to formation of ovarian cysts.... i'm not as sure on this...
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Postby vergil5203 » Thu Apr 05, 2007 10:49 am

O I See,obesity can cause this also.
Progesterone and estrogen cause inhibin on GnRH right? How it is inhibin GnRH hormone for stimulate FSH and LH?
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Postby Revenged » Thu Apr 05, 2007 12:23 pm

vergil5203 wrote:O I See,obesity can cause this also.
Progesterone and estrogen cause inhibin on GnRH right? How it is inhibin GnRH hormone for stimulate FSH and LH?


progesterone and oestrogen inhibit FSH and LH production (the do not stimulate it)...

and i think you mean "inhibition"... "inhibin" is another hormone involved in the control of the menstral cycle... it inhibits the production of FSH...
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Postby vergil5203 » Thu Apr 05, 2007 1:26 pm

ya..is inhibition."typing error"
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Postby vergil5203 » Thu Apr 05, 2007 1:39 pm

Ya,she okay already..

i just wan know more about inhibition in mestrual cycle.
I know the information is Oestrogen n Progesterone use as function.example:promote the development of female secondary sex characteristics

Please descibe the mechanism of inhibition of FSH and LH production.
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Postby Revenged » Thu Apr 05, 2007 8:51 pm

vergil5203 wrote:Ya,she okay already..

i just wan know more about inhibition in mestrual cycle.
I know the information is Oestrogen n Progesterone use as function.example:promote the development of female secondary sex characteristics

Please descibe the mechanism of inhibition of FSH and LH production.


high levels of oestrogen and progesterone inhibit FSH and LH production...

this is how the contraceptive pill works... it contains an oestrogen hormone (mestranol) and a progestogen (norgesterel), which decrease production of FSH and LH...

FSH causes the development of the follicle and LH causes ovulation... and so inhibition of FSH and LH causes prevents ovulation (which is why you are infertile when you take the oral contraceptive pill)...


interestingly, in a man... high levels of testosterone inhibit FSH and LH levels... LH is required by leydig cells of the testis for testosterone synthesis... FSH is required by Sertoli cells of the testis to produce androgen binding factor, which binds testosterone causing higher concentrations of testosterone in the testis than in the rest of the body... if there is low FSH, there is low androgen binding factor, low testosterone levels in the testis, which means that speramatogenesis cannot occur... and so in theory there is potential for making a hormonal male contraceptive in the future...

this negative feedback caused by testosterone is also the reason that abuse of anabolic steroids cause infertility in the male...
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Postby vergil5203 » Fri Apr 06, 2007 9:36 am

I understand already.Thanks a lot
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