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Biology Articles » Biochemistry » Nucleic Acid Biochemistry » Unregulated Hazards ‘Naked’ and ‘Free’ Nucleic Acids » Box 3: Hazards from naked nucleic acids

Box 3: Hazards from naked nucleic acids
- Unregulated Hazards ‘Naked’ and ‘Free’ Nucleic Acids

  • Acute toxic shock from viral vectors
  • Immunological reaction from viral vectors
  • Autoimmune reactions from double-stranded DNA and RNA
  • Non-target interference with gene function from anti-sense DNA, RNA and ribozymes
  • Generation of virulent recombinant viruses
  • Insertion mutagenesis
  • Insertion oncogenesis
  • Genetic contamination of germ cells

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