Accumulating databases in human genome research have enabled integrated genome-wide study on …

• Abstract
• Background
• Methods
• Results
• Discussion
• Conclusion
• Miscellaneous
• References
• Table 1
• Figures

In this study, genome-wide transcriptome overview of colorectal cancers and their precursors were mined from dbEST using an in-house GetUni software. Landscaping the terrain of the transcriptome, new scopes in the initiation and development of colon cancers were implicated. We confirmed that colorectal cancers are genetically heterogeneous. The interactive network among these genes in colorectal cancers became more complicated due to frequent alternative splicing. Aberrations of the ribosome and glycolysis pathway might be early indicators of precursor lesions in colon cancers. Thus, the electronic gene expression profile could be used to highlight the integral molecular events in colorectal cancers. However, more effort should be put into elucidating the regulatory network among these genes via a strategy of system biology, integrating colorectal specific gene expression microarray, microfluidic card Q-PCR and proteomics study.