In this paper, the authors report the structure of the TBLR1 gene …

• Abstract
• Background
• Results
• Discussions and conclusion
• Methods
• References
• Figures
• Tables

1.   Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR: Structure and specificity of nuclear receptor-coactivator interactions.Genes Dev 1998, 12:3343-3356.       2.   Hu I, Lazar MA: Transcriptional Repression by Nuclear Hormone Receptors.Trends Endocrinol Metab 2000, 11:6-10.       3.   Chen JD, Evans RM: A transcriptional co-repressor that interacts with nuclear hormone receptors.Nature 1995, 377:454-457.       4.   Horlein AJ, Na.a.r AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK: Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.Nature 1995, 377:397-404.       5.   Li J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J: Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.EMBO J 2000, 19:4342-4350.       6.   Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, et al.: Combinatorial roles of the nuclear receptor corepressor in transcription and development.Cell 2000, 102:753-763.       7.   Wong CW, Privalsky ML: Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.Mol Cell Biol 1998, 18:5500-5510.       8.   Burke LJ, Baniahmad A: Co-repressors 2000.FASEB J 2000, 14:1876-1888.       9.   Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J: Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.EMBO J 2003, 22:1336-1346.       10.   Zhang J, Kalkum M, Chait BT, Roeder RG: The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.Mol Cell 2002, 9:611-623.       11.   Tomita A, Buchholz DR, Shi Y-B: Recruitment of N-CoR/SMRT-TBLR1 Corepressor Complex by Unliganded Thyroid Hormone Receptor for Gene Repression during Frog Development.Mol Cell Biol 2004, 24:3337-3346.       12.   Xu L, Glass CK, Rosenfeld MG: Coactivator and corepressor complexes in nuclear receptor function.Curr Opin Genet Dev 1999, 9:140-147.       13.   Zhang J, Guenther MG, Carthew RW, Lazar MA: Proteasomal regulation of nuclear receptor corepressor-mediated repression.Genes Dev 1998, 12:1775-1780.       14.   Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R: A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.Genes Dev 2000, 14:1048-1057.       15.   Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA: Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.Genes Dev 2000, 14:45-54.       16.   Zhang X-M, Dormady SP, Basch RS: Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors.Exp Hematol 2000, 28:1286-1296.       17.   Lee DH, Goldberg AL: Proteasome inhibitors: valuable new tools for cell biologists.Trends Cell Biol 1998, 8:397-403.       18.   Neer EJ, Schmidt CJ, Nambudripad R, Smith TF: The ancient regulatory-protein family of WD-repeat proteins.Nature 1994, 371:297-300.       19.   Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G: X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.Am J Hum Genet 1999, 64:1604-1616.       20.   Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.J Cell Biol 1997, 138:375-384.       21.   Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E: The histone deacetylase-3 complex contains nuclear receptor corepressors.Proc Natl Acad Sci USA 2000, %20;97:7202-7207.       22.   Yang XJ, Seto E: Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression.Current Opinion in Genetics & Development 2003, 13:143-153.       23.   Reiner O: LIS1. let's interact sometimes... (part 1).Neuron 2000, 28:633-636.       24.   Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH: Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1.Nat Cell Biol 2000, 2:767-775.       25.   Hirokawa N: Kinesin and dynein superfamily proteins and the mechanism of organelle transport.Science 1998, 279:519-526.       26.   Cerna D, Wilson DK: The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex.J Mol Biol 2005, 351:923-935.       27.   Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O: Novel Functional Features of the Lis-H Domain: Role in Protein Dimerization, Half-life and Cellular Localization.Cell Cycle 2005, 4:1630-1638.       28.   Dong X, Tsuda L, Zavitz KH, Lin M, Li S, Carthew RW, Zipursky SL: ebi regulates epidermal growth factor receptor signaling pathways in Drosophila.Genes Dev 1999, 13:954-965.         29.   Matsuzawa S, Reed JC: Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for beta-Catenin Degradation Linked to p53 Responses.Mol Cell 2001, 7:915-926.       30.   Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG: A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.Cell 2004, 20:511-526.       31.   Yoon HG, Choi Y, Cole PA, Wong J: Reading and Function of a Histone Code Involved in Targeting Corepressor Complexes for Repression.Mol Cell Biol 2005, 25:324-335.       32.   Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA: A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.EMBO J 2003, 22:3403-3410.       33.   DeSalle LM, Pagano M: Regulation of the G1 to S transition by the ubiquitin pathway.FEBS Lett 2001, 490:179-189.       34.   Schwob E, Bohm T, Mendenhall MD, Nasmyth K: The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae.Cell 1994, 79:233-244.         35.   Glotzer M, Murray AW, Kirschner MW: Cyclin is degraded by the ubiquitin pathway.Nature 1991, 349:132-138.       36.   Kipreos ET, Pagano M: The F-box protein family.Genome Biol 2000., 1:     REVIEWS3002   37.   Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N: Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.Mol Cell 2001, 7:927-936.