In an effort to investigate how loss of deneddylation affects SCF activity, …

• Abstract
• Background
• Results
• Discussion
• Conclusion
• Methods
• Abbreviations
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We have shown that CSN can stabilize F-box proteins, thus acting positively on SCF. CSN has been shown to participate in several different processes, including development, transcription, and cell cycle progression [reviewed in [15]]. We propose that loss of deneddylation and a consequent decline in F-box protein abundance underlies these phenotypes.