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In an effort to investigate how loss of deneddylation affects SCF activity, …


Biology Articles » Biochemistry » Protein Biochemistry » Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels » Conclusion

Conclusion
- Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

We have shown that CSN can stabilize F-box proteins, thus acting positively on SCF. CSN has been shown to participate in several different processes, including development, transcription, and cell cycle progression [reviewed in [15]]. We propose that loss of deneddylation and a consequent decline in F-box protein abundance underlies these phenotypes.


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