In this article, many of the whole-animal studies regarding the systemic effects …

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Figure 1. Variation in glomerular filtration rate (GFR). Control arm: mean (SEM) values for GFR for each sampling time in each stage (I–IV) for experiment A (no intervention during the four stages), experiment B (infusion of phenylephrine 15.75 [0.85] U/kg/min during stages II and III), and experiment C (inhaled NO [iNO] 40 ppm during stages II and III). GFR decreased with time in experiment A. Infusion of phenylephrine had no effect on GFR, whereas iNO increased GFR. * Significant difference for analysis of variance (p 5.

Figure 2. Change in arterial diameter at 2 h from baseline control period in cat mesentery superfused with N_ω-nitro-L-arginine methyl ester alone or superfused with N_ω-nitro-L-arginine methyl ester while the cat was treated with 80 ppm inhaled NO. *p 6.

Figure 3. Arterial and venous levels of S-nitrosylated albumin (SNO-Alb; A) and (B) under control and at 30 and 60 min after reperfusion (Rep) in cats breathing NO. Arterial and venous samples for 60 min of inhaled NO are included for comparison. (C) Intestinal blood flow under control, during 60 min of ischemia, and at 30 and 60 min after Rep in animals breathing NO or room air. NO was given to animals at the onset of reperfusion. Data are presented as mean ± SEM. *p +p 9.

Source: The Proceedings of the American Thoracic Society 3:170-172 (2006).