Welcome to biology-online.org! Please login to access all site features. Create an account.
Log me on automatically each visit
This article reviews some of the recent findings resulting from tissue engineering …
Biology Articles » Bioengineering » Skeletal muscle tissue engineering » Tissue engineering in vivo - in vitro
Therapeutic treatments for acquired and inherited skeletal myopathies and loss of functional muscle tissue require the ability to either the implantion of differentiated muscle tissue constructs or the injection of muscle-precursor cells into sites of dysfunction or tissue deficiency for subsequent formation of new muscle tissue  . The implantation of engineered myoblasts has been utilized as a poten
In contrast to these myoblast transfer strategies, other researchers in the field of muscle tissue engineering are more focussing on in vitro differentiation and maturation of satellite cells harvested from adult skeletal muscle. This approach of in vitro development of bioartificial muscle could be an alternative source for treating muscular disorders as described above  . These attempts reflect the two general approaches to engineer skeletal muscle tissue. One approach uses in vitro-designed and pre-fabricated artificial muscle tissue equivalents to reimplant the neo-tissue after differentiation has taken place (in vitro tissue engineering) (Fig. 1A). The second approach uses the application of isolated satellite cells, after expansion of cells in vitro using an appropriate transport matrix, which allows differentiation into myotubes in vivo to occur (in vivo tissue engineering) (Fig.1B). Future developments and the decision regarding which approach is more promising depend on the elucidation of the relationships among cell growth and and differentiation, the cell integration capacity in the host in in vivo experiments and the capability to induce vascularisation of tissue equivalents in vitro.
rating: 2.40 from 10 votes | updated on: 30 Sep 2006 | views: 17467 |
share this article | email to friends
suggest a revision
print this page
print the whole article
© Biology-Online.org. All Rights Reserved. Register | Login | About Us | Contact Us | Link to Us | Disclaimer & Privacy