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Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic …


Biology Articles » Biochemistry » Lipid Biochemistry » Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach » Introduction

Introduction
- Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach

The enzyme butyrylcholinesterase (BChE; EC 3.1.1.1.8) has a well-defined pharmacologic function in hydrolyzing succinylcholine, a muscle relaxant used in anesthetic practice. It could have other roles, though much less well defined, such as modulating the phenotypic expression of dyslipidemia and metabolic syndrome. Serum levels of the enzyme are affected by dietary fat, obesity, hyperlipidemia and diabetes mellitus [1].

With genomic sequences from many species being available in the public domain [2], it is possible to annotate proteins in evolutionarily terms. Such analysis is particularly useful for proteins with poorly defined physiological role, such as BchE. A phylogenetic analysis of amino acid/ nucleotide sequences could throw light on 'how the family might have been derived during evolution' [3]. The analysis is represented as an evolutionary tree, which is a two-dimensional graph; it shows evolutionary relationships of genes from different organisms.

Here we (a) studied the level of BChE among persons with diabetes mellitus (b) constructed the phylogenetic tree of 25 BChE genes from publicly available sequence data.


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