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Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic …


Biology Articles » Biochemistry » Lipid Biochemistry » Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach

Abstract
- Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach

Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach

GR Sridhar2, G Nirmala2, Allam Apparao1, AS Madhavi1, S Sreelatha1, J Sudha Rani1 and P Vijayalakshmi1

1Department of Computer Science and Systems Engineering, Andhra University, Visakhapatnam, India

2Endocrine and Diabetes Centre, 15-12-16 Krishnanagar, Visakhapatnam 530 002, India

Open access article from Lipids in Health and Disease 2005, 4:18.


Abstract

Background

Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide sequences downloaded from NCBI. Butyrylcholinesterase was estimated colorimetrically using a commercially available kit (Randox Lab, UK). Phylogenetic trees were constructed by distance method (Fitch and Margoliash method) and by maximum parsimony method.

Results

There was a negative correlation between serum total cholesterol and butyrylcholinesterase (-0.407; p < 0.05) and between serum LDL cholesterol and butyrylcholinesterase (-0.435; p < 0.05). There was no statistically significant correlation among the other biochemical parameters. In the evolutionary tree construction both methods gave similar trees, except for an inversion in the position of Sus scrofa (M62778) and Oryctolagus cuniculus (M62779) between Fitch and Margoliash, and maximum parsimony methods.

Conclusion

The level of butyrylcholinesterase enzyme was inversely related to serum cholesterol; dendrogram showed that the structures from evolutionarily close species were placed near each other.

 

Keywords: metabolic syndrome, type 2 diabetes, dyslipidemia, phylogenetic tree, evolutionary distance


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