Scientific evidence of the significant anti-cancer effect of milk thistle
November 15, 2007 -- Recently, scientists demonstrated the anti-cancer effects of silibinin,
a major biologically active compound of milk thistle. Being widely used
as a folk remedy for liver diseases, milk thistle is safe and
well-tolerated, and it protects the liver from drug or alcohol-related
injury. Silibinin is highly purified from milk thistle, with a defined
chemical structure and molecular weight (C25H22O10, MW: 482.44).
Dr. Hu and his colleagues' discovery of silibiling's anti-liver cancer
effects was published in the October 28 issue of the World Journal of
Gastroenterology. The researchers found that silibilin can
significantly reduce the growth of several human hepatoma cell lines.
In addition, they demonstrated that silibinin mediates anti-liver
cancer effects by (1) reduced cancer cell proliferation and cell cycle
progression; (2) enhanced programmed death of cancer cells; and (3)
altered chromatin structure of the cancer cells.
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